D2944
抗-D1 多巴胺受体抗体，大鼠单克隆抗体 大鼠抗
clone 1-1-F11 s.E6, purified from hybridoma cell culture
别名:
抗 DRD1
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关于此项目
Conjugate:
unconjugated
Clone:
1-1-F11 s.E6, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rat, monkey, human
Citations:
60
Technique(s):
immunocytochemistry: 5-10 μg/mL using D1 dopamine receptor transfected HEK-293T cells
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-D1 多巴胺受体抗体，大鼠单克隆抗体 大鼠抗, clone 1-1-F11 s.E6, purified from hybridoma cell culture
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
1-1-F11 s.E6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
rat, monkey, human
concentration
~1 mg/mL
technique(s)
immunocytochemistry: 5-10 μg/mL using D1 dopamine receptor transfected HEK-293T cells
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DRD1(1812)
rat ... Drd1a(24316)
Application
大鼠单克隆抗D1多巴胺受体抗体可用于：
- 免疫组化
- 免疫印迹
- 免疫细胞化学
- 邻位连接检测
- 免疫共沉淀
- 蛋白质印迹
Biochem/physiol Actions
D1 受体调节神经元生长和发育，介导一些行为反应，并调节多巴胺受体D2介导的事件。D1 受体在气道平滑肌（ASM）上表达，通过 cAMP 激活蛋白激酶 A 调节平滑肌张力。它是治疗性 ASM 松弛的潜在靶点。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
D1 多巴胺受体编码多巴胺受体的 D1 亚型。D1 亚型是中枢神经系统中含量最丰富的多巴胺受体。这种 G 蛋白偶联受体刺激腺苷酸环化酶并激活环腺苷酸依赖性蛋白激酶。
单克隆抗D1多巴胺受体（大鼠IgG2a同种型）来源于通过融合小鼠骨髓瘤细胞而杂交瘤1-1-F11 S.E6和使用含人D1多巴胺受体C-端97氨基酸重组融合蛋白免疫大鼠脾细胞。多巴胺受体属于7个跨膜结构域G蛋白偶联受体家族。多巴胺受体主要分布在纹状体、边缘系统、大脑皮层和下丘脑漏斗。D1类家族包括D1受体和D5受体。
Immunogen
含有人多巴胺 D 1 受体 C 末端 97 氨基酸的重组融合蛋白。
Legal Information
根据埃默里大学的独家许可证销售
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Impact of early consumption of high-fat diet on the mesolimbic dopaminergic system
Naneix F, et al.
eNeuro, 4(3) (2017)
D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses
Cahill E, et al.
Molecular Psychiatry, 19(12), 1295-1295 (2014)
Kentaro Mizuta et al.
Respiratory research, 14, 89-89 (2013-09-06)
Dopamine signaling is mediated by Gs protein-coupled "D1-like" receptors (D1 and D5) and Gi-coupled "D2-like" receptors (D2-4). In asthmatic patients, inhaled dopamine induces bronchodilation. Although the Gi-coupled dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth
A L Frederick et al.
Molecular psychiatry, 20(11), 1373-1385 (2015-01-07)
Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation, because their purported potential to manifest signaling and pharmacological properties that differ from the component receptors makes them highly attractive for the development of more selective pharmacological treatments. In
Satoshi Goto et al.
Frontiers in neuroanatomy, 9, 22-22 (2015-03-19)
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of
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