D1542
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇 盐酸盐
≥98% (TLC), Glycogen phosphorylase inhibitor, solid
别名:
2-羟甲基-3,4-吡咯烷二醇 盐酸盐
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关于此项目
经验公式（希尔记法）:
C5H11NO3 · HCl
化学文摘社编号:
分子量:
169.61
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇 盐酸盐, enzyme inhibitor
SMILES string
Cl.OC[C@H]1NC[C@@H](O)[C@@H]1O
InChI key
PZGVJCJRMKIVLJ-DEVUXVJFSA-N
InChI
1S/C5H11NO3.ClH/c7-2-3-5(9)4(8)1-6-3;/h3-9H,1-2H2;1H/t3-,4-,5-;/m1./s1
assay
≥98% (TLC)
form
solid
storage condition
under inert gas
solubility
water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... PYGB(5834), PYGBL(5835), PYGL(5836), PYGM(5837)
mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Pygl(64035), Si(25588)
General description
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇是一种天然存在的吡咯烷生物碱。它存在于Arachniodes standishii 和 Angylocalyx boutiqueanus中。
Application
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇盐酸盐已用作α-葡萄糖苷酶（GAA）抑制剂。
Biochem/physiol Actions
糖原磷酸化酶和α-葡萄糖苷酶的抑制剂。
Disclaimer
极易吸湿，在氩中储存和处理
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A new resorufin-based $\alpha$-glucosidase assay for high-throughput screening
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The synthesis from d-xylose of the potent and specific enantiomeric glucosidase inhibitors, 1, 4-dideoxy-1, 4-imino-d-arabinitol and 1, 4-dideoxy-1, 4-imin
Fleet GWJ and Smith PW
Tetrahedron, 42(20), 5685-5692 (1986)
Ze Fan et al.
Neuroscience bulletin, 36(12), 1513-1523 (2020-10-14)
General anesthesia severely affects the metabolites in the brain. Glycogen, principally stored in astrocytes and providing the short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role in modulating anesthesia-arousal
E Vezzoli et al.
Cerebral cortex (New York, N.Y. : 1991), 30(4), 2114-2127 (2019-12-07)
Long-term memory formation (LTM) is a process accompanied by energy-demanding structural changes at synapses and increased spine density. Concomitant increases in both spine volume and postsynaptic density (PSD) surface area have been suggested but never quantified in vivo by clear-cut
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