About This Item
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生物来源
synthetic (organic)
质量水平
方案
98.0-102.0% (HPLC)
表单
powder
mp
216 °C (dec.) (lit.)
溶解性
water: 50.0-52.0 mg/mL, clear, orange to red
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
储存温度
2-8°C
SMILES字符串
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
基因信息
human ... TOP2A(7153)
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一般描述
道诺霉素也导致活性氧(ROS)的生成，后者进一步破坏DNA、蛋白质和膜。 它具有细胞毒性、抗肿瘤、抗癌活性，可应用于癌症、代谢组学、细胞生物学和生物化学研究。
应用
- 细胞活力测定
- MTT（3-(4,5-二甲基-2-噻唑基)-2,5-二苯基四唑的溴盐）测定
- 用作PLGA基聚合物微粒药物递送的药物
- 开发抗阿霉素的HepG2细胞 (HepG2-DR)和K562细胞(K562-DR)
生化/生理作用
特点和优势
- 适合多种研究应用的高质量抗生素
- 非常适合细胞生物学、代谢组学、生化研究。
制备说明
储存及稳定性
相关产品
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
历史批次信息供参考:
分析证书(COA)
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the excitation and emission wavelength for Product D1515, Doxorubicin hydrochloride?
Doxorubicin has excitation maximum at 470 nm and an emission maximum at 585 nm in ethanol.
What is the difference between Doxorubicin hydrochloride Products D1515 and D1317?
Product No. D1317, Doxorubicin hydrochloride solution has been discontinued and is no longer available. We now offer Product No. D1515 which is a powder.
How can I store a solution of Product D1515, Doxorubicin hydrochloride?
Aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at <0.5 mg/mL, with considerable loss of bioactivity. If stored at 25 °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks.
What can be used to make a solution of Product D1515, Doxorubicin hydrochloride?
The solubility of doxorubicin is tested in water (50 mg/mL), yielding a clear orange to red solution.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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