D1260
十烃溴铵
crystalline
别名:
溴化十烃季胺, 溴化癸烷双胺
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关于此项目
线性分子式:
(CH3)3N(Br)(CH2)10N(Br)(CH3)3
化学文摘社编号:
分子量:
418.29
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
208-772-2
Beilstein/REAXYS Number:
3728288
MDL number:
InChI
1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
InChI key
HLXQFVXURMXRPU-UHFFFAOYSA-L
SMILES string
[Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
form
crystalline
color
off-white
mp
263-267 °C (lit.)
originator
GlaxoSmithKline
Quality Level
Gene Information
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相关类别
Application
Decamethonium bromide has been used to induce paralysis in duck embryo.
Biochem/physiol Actions
Decamethonium serves as a muscle relaxant and is also a neuromuscular blocking agent. It has a molecular weight of 258.4.
Nicotinic acetylcholine receptor partial agonist and neuromuscular blocking agent; depolarizes striated muscles and blocks their activity.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
D Bertrand et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(5), 1993-1997 (1990-03-01)
Neuronal nicotinic acetylcholine receptor of the alpha 4/non-alpha (alpha 4/n alpha) type was reconstituted in Xenopus oocytes after nuclear injection of cDNA expression vectors. Functional neuronal receptor was only formed when the two subunits alpha 4 and n alpha were
Mesenchymal and mechanical mechanisms of secondary cartilage induction
Solem R C, et al.
Developmental Biology, 356(1), 28-39 (2011)
Dana B Finley et al.
Journal of pharmacological and toxicological methods, 59(2), 108-119 (2009-04-16)
Exposure to irreversible cholinesterase (ChE)-inhibiting compounds, such as organophosphates may produce neuromuscular dysfunction. However, less is known about changes in neuromuscular transmission after treatment with reversible ChE-inhibitors. These studies adapted single fiber electromyography (SFEMG) techniques to quantify neuromuscular jitter in
Roger L Papke et al.
The Journal of pharmacology and experimental therapeutics, 333(2), 501-518 (2010-01-27)
Transgenic mouse models with nicotinic acetylcholine receptor (nAChR) knockouts and knockins have provided important insights into the molecular substrates of addiction and disease. However, most studies of heterologously expressed neuronal nAChR have used clones obtained from other species, usually human
I Wenningmann et al.
Molecular pharmacology, 60(3), 584-594 (2001-08-15)
We performed macroscopic and single-channel current measurements on wild-type (WT) and two mutant muscle-type nicotinic acetylcholine (ACh) receptor channels transiently expressed in HEK-293 cells. The mutants contained polar-to-nonpolar substitutions at the 10' (alpha(2)S10'A beta T10'A gamma delta) and 6' positions
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