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D1064

Sigma-Aldrich

二氢红藻氨酸

≥98% (HPLC), powder

别名:

2-羧基-4-异丙基-3-吡咯烷乙酸

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About This Item

经验公式（希尔记法）:
C10H17NO4
CAS号:
52497-36-6
分子量:
215.25
MDL编号:
MFCD03412037
UNSPSC代码:
12352106
PubChem化学物质编号:
24277981
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

溶解性

H2O: >10 mg/mL

储存温度

2-8°C

SMILES字符串

CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI

1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChI key

JQPDCKOQOOQUSC-OOZYFLPDSA-N

基因信息

human ... SLC1A1(6505) , SLC1A2(6506) , SLC1A3(6507)
rat ... Slc1a2(29482) , Slc1a3(29483)

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应用

在星形胶质细胞和神经胶质细胞的谷氨酸摄取测试中，二氢红藻氨酸（dihydrokainic acid）已被用作谷氨酸转运蛋白（GLT-1）抑制剂。它可以用作外侧缰核（Lateral habenula，LHb）中的GLT-1抑制剂。

生化/生理作用

二氢海藻酸是GLT-1谷氨酸转运蛋白的选择性抑制剂。在较高浓度下，二氢海藻酸酯是AMPA /海藻酸酯谷氨酸受体的弱抑制剂。
二氢红藻氨酸会促进神经元细胞死亡。它可调节焦虑和抑郁行为。
二氢红藻氨酸是一种选择性 GLT-1 谷氨酸转运体抑制剂；高浓度 AMPA/红藻氨酸谷氨酸受体的弱抑制剂。

特点和优势

该化合物收录于 《受体分类和信号转导》手册的兴奋性氨基酸转运体页面。想要浏览手册的其他页面， 请单击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000382368
0000382367
0000374645
0000382368
0000382367

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Scott M Rawls et al.
Drug and alcohol dependence, 107(2-3), 261-263 (2009-12-17)
Glutamate transporter subtype 1 (GLT-1) activation is a promising - and understudied - approach for managing aspects of morphine tolerance caused by increased glutamatergic transmission. Identification of beta-lactam antibiotics as pharmaceuticals which activate GLT-1 transporters prompted us to hypothesize that
Katrien C K Poelaert et al.
mBio, 12(2) (2021-03-25)
Viruses, including members of the herpes-, entero-, and morbillivirus families, are the most common cause of infectious encephalitis in mammals worldwide. During most instances of acute viral encephalitis, neurons are typically the initial cell type that is infected. However, as
Rescue of glutamate transport in the lateral habenula alleviates depression-and anxiety-like behaviors in ethanol-withdrawn rats
Kang S, et al.
Neuropharmacology, 129(11), 47-56 (2018)
Anita J Bechtholt-Gompf et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2049-2059 (2010-06-10)
Mood disorders are associated with regional brain abnormalities, including reductions in glial cell and neuron number, glutamatergic irregularities, and differential patterns of brain activation. Because astrocytes are modulators of neuronal activity and are important in trafficking the excitatory neurotransmitter glutamate
Catherine S John et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(11), 2467-2475 (2012-06-29)
Major depression is associated with both dysregulated glutamatergic neurotransmission and fewer astrocytes in limbic areas including the prefrontal cortex (PFC). These deficits may be functionally related. Notably, astrocytes regulate glutamate levels by removing glutamate from the synapse via the glutamate
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