所有图片(3)
别名:
（±）-1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷 盐酸盐, （±）-2,5-二甲氧基-4-碘代苯丙胺 盐酸盐, （±）-DOI
经验公式（希尔记法）:
C11H16INO2 · HCl
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
drug control
Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
white to off-white
溶解性
H2O: 10 mg/mL
ethanol: 2 mg/mL
SMILES字符串
NC(C)CC1=CC(OC)=C(I)C=C1OC.Cl
InChI
1S/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H
InChI key
QVFDMWGKHUFODK-UHFFFAOYSA-N
基因信息
human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
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生化/生理作用
（±）-DOI盐酸盐是一种强效和选择性的5-HT2血清素受体激动剂，可穿过血脑屏障，增加多巴胺的周转，用DOI治疗可对抗尼古丁诱导的运动和神经化学敏化的表达，但对尼古丁诱导的行为去抑制没有影响。它对DOI的反应提供了证据，证明这些受体在皮质中含量丰富，在海马和小脑中含量相对较低。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum.
J Ichikawa et al.
Brain research, 698(1-2), 204-208 (1995-11-06)
The effects of (+-)-DOI (1-(2,5-dimethoxy-4-iodophenyl)-aminopropane) hydrochloride, a mixed 5-HT2A/2C receptor agonist, on the release of dopamine (DA) following D-amphetamine sulfate (AMP) or a DA D2 autoreceptor selective dose of (-)-apomorphine hydrochloride (APO), were investigated in rat striatum (STR) and nucleus
G J Marek et al.
The Journal of pharmacology and experimental therapeutics, 278(3), 1373-1382 (1996-09-01)
Correlations between 5-hydroxytryptamine (5-HT) receptor binding affinities and human hallucinogenic potency have suggested that 5-HT2 receptors mediate the hallucinogenic effects of lysergic acid diethylamide (LSD) and phenethylamine hallucinogens. Electrophysiological studies have suggested that a subpopulation of gamma-aminobutyric acid (GABA)ergic interneurons
R Gaggi et al.
General pharmacology, 28(4), 583-587 (1997-04-01)
1. The behavioral responses, as well as the biogenic amines and metabolite contents in discrete brain areas were determined in male rats subcutaneously treated with a 5-HT1A (8-OHDPAT) or 5-HT2A (DOI) agonist at doses (0.5-2 mg/kg) sufficient to produce the
Jingya Ruan et al.
Molecules (Basel, Switzerland), 25(17) (2020-08-28)
Yucca schidigera Roezl (Mojave), a kind of ornamental plant belonging to the Yucca genus (Agavaceae), whose extract exhibits important roles in food, beverage, cosmetic and feed additives owing to its rich spirostanol saponins. To provide a comprehensive chemical profiling of
Joe Anand Kumar John Jayakumar et al.
Scientific reports, 10(1), 21675-21675 (2020-12-12)
5-HT2A, a G-protein coupled receptor, is widely expressed in the human body, including in the gastrointestinal tract, platelets and the nervous system. It mediates various functions, for e.g. learning, memory, mood regulation, platelet aggregation and vasoconstriction, but its involvement in
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