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D054

R（+）-SCH-23390 盐酸盐

Name: R（+）-SCH-23390 盐酸盐
Brand: SIGMA

≥98% (HPLC), dopamine receptor antagonist, solid

别名:

R（+）-7-氯-8-羟基-3-甲基-1-苯基-2，3，4，5-四氢-1H-3-苯并氮杂盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₈ClNO · HCl

化学文摘社编号:

125941-87-9

分子量:

324.24

UNSPSC Code:

12352200

PubChem Substance ID:

24277910

NACRES:

NA.77

MDL number:

MFCD00069249

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated, protect from light

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产品名称

R（+）-SCH-23390 盐酸盐, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]/D +32.1°, c = 1 in DMF(lit.)

storage condition

desiccated, protect from light

color

white

solubility

H₂O: >5 mg/mL

SMILES string

Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3

InChI

1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChI key

OYCAEWMSOPMASE-XFULWGLBSA-N

Gene Information

human ... DRD1(1812)

Application

R(+)-SCH-23390盐酸盐可用于：

腹腔注射实验大鼠，研究D1受体在致敏性中的作用
作为D1受体选择性拮抗剂，注入颅内药物
作为D1受体拮抗剂，研究其对鱼类学习能力的影响

Biochem/physiol Actions

R(+)-SCH-23390盐酸盐是一种选择性D1多巴胺受体拮抗剂。在体外对5-羟色胺2 (5-HT2)和5-HT1C 血清素受体亚型具有更强的结合力。给药后R(+)-SCH-23390的半衰期为25分钟。众所周知，它具有抗定型和促僵硬作用。此外，它还对肌动活动有抑制作用。

Features and Benefits

受体分类和信号转导手册的多巴胺受体和钾通道页面重点介绍了该化合物。想要浏览手册的其他页面，请单击此处。

Legal Information

经先灵葆雅许可出售。

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000428069

0000338113

0000338115

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Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)

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SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in

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Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)

D1 receptor-mediated endogenous tPA upregulation contributes to blood-brain barrier injury after acute ischaemic stroke.

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Journal of cellular and molecular medicine, 24(16), 9255-9266 (2020-07-07)

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Steinberg E E, et al.

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全球贸易项目编号

货号	GTIN
D054-5MG	04061833557822
D054-25MG	04061833557815
D054-100MG	04061832090108
D054-10MG	04061833557808

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