跳转至内容
Merck
CN
所有图片(4)

主要文件

查看所有文档

安全信息

C9911

Sigma-Aldrich

(S)-(+)-喜树碱

≥90% (HPLC), powder, DNA topoisomerase I inhibitor

别名:

(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

登录查看公司和协议定价
所有图片(4)

About This Item

经验公式（希尔记法）:
C20H16N2O4
CAS号:
7689-03-4
分子量:
348.35
Beilstein:
631069
MDL编号:
MFCD00081076
UNSPSC代码:
12352200
PubChem化学物质编号:
24278352
NACRES:
NA.77

产品名称

(S)-(+)-喜树碱, ≥90% (HPLC), powder

质量水平

200

方案

≥90% (HPLC)

表单

powder

mp

260 °C (dec.) (lit.)

溶解性

chloroform/methanol (4:1): 5 mg/mL

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES字符串

CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O

InChI

1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

InChI key

VSJKWCGYPAHWDS-FQEVSTJZSA-N

基因信息

human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Sstr2(54305)

正在寻找类似产品? 访问 产品对比指南

生化/生理作用

(S)-(+)-喜树碱和DNA拓扑异构酶I复合体不可逆地结合，抑制拓扑异构酶I剪切后DNA重组，将酶和DNA以共价键形式锁住。酶复合体被泛素化，被26S蛋白酶破坏，耗尽细胞内拓扑异构酶I。该酶在低剂量下在S期阻碍细胞周期，在大多数正常和肿瘤细胞中通过依赖细胞周期和不依赖细胞周期的过程诱发细胞凋亡。

特点和优势

该化合物是细胞凋亡研究的特色产品。点击此处 ，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

其他说明

20S异构体

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301,H340

危险分类

Acute Tox. 3 Oral - Muta. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

涉药品监管产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
WXBF3438V
WXBF0050V
WXBD6035V
WXBD4658V
WXBD3639V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3.  What is Product C9911, (S)-(+)-Camptothecin, soluble in?

    This product is soluble in DMSO (10 mg/mL). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95°C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/mL).

  4. What is the solution stability of Product C9911, (S)-(+)-Camptothecin?

    Stock solutions of camptothecin in DMSO can be stored at -20°C for up to 3 months.

  5. What is the extinction coefficient of Product C9911, (S)-(+)-Camptothecin?

    The millimolar extinction coefficients (EmM) at various wavelengths are 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm).

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Qi Weng et al.
Cancer chemotherapy and pharmacology, 84(3), 527-537 (2019-04-29)
Recent researches are attempting to verify that the 3D cell models can provide a gap bridge between in vitro and in vivo for anticancer drug evaluations. The aim of this study was to continue the development of novel in vitro
Dinh Trung Nguyen et al.
Polymers, 11(5) (2019-05-10)
Herein, a new process to manufacture multicore micelles nanoparticles reinforced with co-assembly via hydrophobic interaction and electrostatic interaction under the help of ultrasonication was developed. The precise co-assembly between negative/hydrophobic drug and positive charged amphiphilic copolymer based pluronic platform allows
H-S Chen et al.
European review for medical and pharmacological sciences, 23(15), 6621-6628 (2019-08-06)
MicroRNAs (miRNAs) are a conserved class of endogenous and short non-coding RNAs that post-transcriptionally regulate the expression of genes involved in diverse cellular processes. MiR-28-5p has been reported to be associated with several cancers, including human glioma. However, the roles
Pinakin Pandya et al.
Cellular signalling, 62, 109340-109340 (2019-06-09)
Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Glrx3)) is a ubiquitously expressed protein that possesses an N-terminal monothiol thioredoxin (Trx) domain and two C-terminal tandem copies of a monothiol Glrx domain. It has an overall
Gudrun Meinhardt et al.
Scientific reports, 6, 28127-28127 (2016-06-18)
The maternal uterine environment is likely critical for human placental morphogenesis and development of its different trophoblast subtypes. However, factors controlling growth and differentiation of these cells during early gestation remain poorly elucidated. Herein, we provide evidence that the ligand
查看所有相关文献

商品

Autophagy in Cancer Promotes Therapeutic Resistance

We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门