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Merck
CN

C8249

Sigma-Aldrich

小豆蔻明

≥98% (HPLC)

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别名:
(2E)-1-(2,4-二羟基-6-甲氧基苯基)-3-苯基-2-丙烯-1-酮, (8CI);川陈皮素查尔酮, (E)-2′,4′-二羟基-6′-甲氧基查尔酮
经验公式(希尔记法):
C16H14O4
CAS号:
分子量:
270.28
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

light yellow to dark brown

溶解性

DMSO: ≥20 mg/mL

储存温度

room temp

SMILES字符串

O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC

InChI

1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

InChI key

NYSZJNUIVUBQMM-BQYQJAHWSA-N

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应用

小豆蔻明已被用作糖原合酶激酶3(GSK3)抑制剂,用于研究其对植入前人胚胎中β-连环蛋白功能缺失和获得(loss and gain-of-function)的影响。
小豆蔻明已被用作高效液相色谱(HPLC)分析金合欢(acacia)蜂蜜样品中酚类化合物中的标准品。

生化/生理作用

小豆蔻醚 (Cardamonin) 是一种来自豆蔻属(姜科植物)的植物。小豆蔻醚通过抑制 Wnt/β-连环蛋白 信号通路抑制黑素细胞色素沉着。小豆蔻醚通过蛋白酶体介导降解 β-连环蛋白(GSK-3β 非依赖性途径)抑制 Wnt/β-连环蛋白信号通路。研究表明,小豆蔻醚通过抑制 NF-kB 核转位和 Ik-Ba 磷酸化而具有抗炎活性。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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