C8249
小豆蔻明
≥98% (HPLC), glycogen synthase kinase 3 (GSK3) inhibitor, powder
别名:
(2E)-1-（2,4-二羟基-6-甲氧基苯基）-3-苯基-2-丙烯-1-酮, (8CI)；川陈皮素查尔酮, (E)-2′,4′-二羟基-6′-甲氧基查尔酮
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关于此项目
经验公式（希尔记法）:
C16H14O4
化学文摘社编号:
分子量:
270.28
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
小豆蔻明, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
light yellow to dark brown
溶解性
DMSO: ≥20 mg/mL
储存温度
room temp
SMILES字符串
O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC
InChI
1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
InChI key
NYSZJNUIVUBQMM-BQYQJAHWSA-N
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应用
小豆蔻明已被用作糖原合酶激酶3（GSK3）抑制剂，用于研究其对植入前人胚胎中β-连环蛋白功能缺失和获得（loss and gain-of-function）的影响。
小豆蔻明已被用作高效液相色谱（HPLC）分析金合欢（acacia）蜂蜜样品中酚类化合物中的标准品。
生化/生理作用
小豆蔻醚 (Cardamonin) 是一种来自豆蔻属（姜科植物）的查耳酮。
小豆蔻醚 (Cardamonin) 是一种来自豆蔻属（姜科植物）的植物。小豆蔻醚通过抑制 Wnt/β-连环蛋白 信号通路抑制黑素细胞色素沉着。小豆蔻醚通过蛋白酶体介导降解 β-连环蛋白（GSK-3β 非依赖性途径）抑制 Wnt/β-连环蛋白信号通路。研究表明，小豆蔻醚通过抑制 NF-kB 核转位和 Ik-Ba 磷酸化而具有抗炎活性。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Peiguang Niu et al.
Oncology letters, 15(3), 3991-3997 (2018-02-20)
The mammalian target of rapamycin (mTOR) is well-known as a promising therapeutic target in various cancer cells. mTOR activation decreases the sensitivity of ovarian cancer to cisplatin. Cardamonin inhibits the proliferation of various cancer cells by mTOR suppression. The present
Bokyung Sung et al.
PloS one, 8(5), e64118-e64118 (2013-05-22)
Bone loss/resorption or osteoporosis is a disease that is accelerated with aging and age-associated chronic diseases such as cancer. Bone loss has been linked with human multiple myeloma, breast cancer, and prostate cancer and is usually treated with bisphosphonates, and
Deyong Jia et al.
Oncotarget, 7(1), 771-785 (2015-10-28)
The failure of cytotoxic chemotherapy in breast cancers has been closely associated with the presence of drug resistant cancer stem cells (CSCs). Thus, screening for small molecules that selectively inhibit growth of CSCs may offer great promise for cancer control
Chih-Chien Wang et al.
Medicina (Kaunas, Lithuania), 57(9) (2021-09-29)
Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1β, which in turn lead to
Jianqing Jiang et al.
Journal of microbiology and biotechnology, 31(6), 794-802 (2021-05-25)
In this study we investigated the role and mechanism of cardamonin on IL-1β induced injury in OA. CHON-001 cells were treated with cardamonin and IL-1β and transfected with silencing nuclear factor erythroid 2-related factor 2 (siNrf2). Cell viability was detected
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