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重组
expressed in Pichia pastoris
质量水平
表单
liquid
比活
≥40 units/mg protein
分子量
~37 kDa by SDS-PAGE
浓度
125-400 μg/mL
UniProt登记号
应用
diagnostic assay manufacturing
运输
dry ice
储存温度
−20°C
基因信息
human ... CMA1(1215)
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应用
在一项研究中，使用人糜酶来评估三七花提取物对心脏重构中TGFβ/ Smad信号转导途径的影响。 人糜酶也已被用于一项研究中，以研究链脲佐菌素处理的人糜酶转基因小鼠的血糖水平和存活率。
胸苷酶与血管紧张素II的产生和大内皮素的裂解有关。研究表明它可能与血管增生、心肌梗塞和皮炎有关。
生化/生理作用
该酶可迅速将血管紧张素 I 转化为血管紧张素 II。酶活性的最适 pH 值为 7.5 ~ 9.0。大豆胰蛋白酶抑制剂、苯甲基磺酰氟和糜蛋白酶抑制剂可抑制酶的活性。
物理属性
糜蛋白酶是一种主要存在于肥大细胞的组织蛋白酶G样S1丝氨酸蛋白酶。它的分子量约为30 kDa，但在SDS-PAGE上的表观分子量约为37 kDa。
单位定义
在 pH 7.8 和 25°C 条件下，1 个单元每分钟水解 1 μmol N-苯甲酰-L-酪氨酸乙酯 (BTEE)。用于测定酶活性的试验缓冲液含 27 mM Tris-HCl (pH 7.8)、150 mM NaCl 和 0.43 mM BTEE。
外形
以溶于 20 mM Tris、0.8 MNaCl 和 25% 甘油的溶液 (pH 7.6) 形式提供
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Laurent L Reber et al.
Journal of immunology (Baltimore, Md. : 1950), 192(4), 1847-1854 (2014-01-24)
Mast cells (MCs) are found in large numbers in lungs of patients with pulmonary fibrosis. However, the functions of MCs in lung fibrosis remain largely unknown. We assessed the role of MCs and MC protease 4 (MCPT4), the mouse counterpart
Thomas Lind et al.
Matrix biology : journal of the International Society for Matrix Biology, 112, 1-19 (2022-08-01)
Mast cells have been linked to osteoporosis and bone fractures, and in a previous study we found that mice lacking a major mast cell protease, chymase, develop increased diaphyseal bone mass. These findings introduce the possibility that mast cell chymase
Lora G Bankova et al.
Journal of immunology (Baltimore, Md. : 1950), 192(6), 2812-2820 (2014-02-14)
We previously established a mast cell (MC)-dependent thermal injury model in mice with ulceration and scar formation that depended on nonredundant functions of mouse MC protease (mMCP)4 and mMCP5. We hypothesized that MC activation is an early event and now
J C Powers et al.
Biochemistry, 24(8), 2048-2058 (1985-04-09)
The extended substrate binding sites of several chymotrypsin-like serine proteases, including rat mast cell proteases I and II (RMCP I and II, respectively) and human and dog skin chymases, have been investigated by using peptide 4-nitroanilide substrates. In general, these
I Waern et al.
Mucosal immunology, 6(5), 911-920 (2012-12-14)
Mast cells (MCs) are major effector cells contributing to allergic conditions. When activated, they can release large amounts of active proteases, including chymase from their secretory granules. Here we assessed the role of the chymase mouse mast cell protease 4
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