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重组
expressed in Pichia pastoris
质量水平
表单
liquid
比活
≥40 units/mg protein
分子量
~37 kDa by SDS-PAGE
浓度
125-400 μg/mL
UniProt登记号
应用
diagnostic assay manufacturing
运输
dry ice
储存温度
−20°C
基因信息
human ... CMA1(1215)
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应用
在一项研究中，使用人糜酶来评估三七花提取物对心脏重构中TGFβ/ Smad信号转导途径的影响。 人糜酶也已被用于一项研究中，以研究链脲佐菌素处理的人糜酶转基因小鼠的血糖水平和存活率。
胸苷酶与血管紧张素II的产生和大内皮素的裂解有关。研究表明它可能与血管增生、心肌梗塞和皮炎有关。
生化/生理作用
该酶可迅速将血管紧张素 I 转化为血管紧张素 II。酶活性的最适 pH 值为 7.5 ~ 9.0。大豆胰蛋白酶抑制剂、苯甲基磺酰氟和糜蛋白酶抑制剂可抑制酶的活性。
物理属性
糜蛋白酶是一种主要存在于肥大细胞的组织蛋白酶G样S1丝氨酸蛋白酶。它的分子量约为30 kDa，但在SDS-PAGE上的表观分子量约为37 kDa。
单位定义
在 pH 7.8 和 25°C 条件下，1 个单元每分钟水解 1 μmol N-苯甲酰-L-酪氨酸乙酯 (BTEE)。用于测定酶活性的试验缓冲液含 27 mM Tris-HCl (pH 7.8)、150 mM NaCl 和 0.43 mM BTEE。
外形
以溶于 20 mM Tris、0.8 MNaCl 和 25% 甘油的溶液 (pH 7.6) 形式提供
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Su Duy Nguyen et al.
Journal of lipid research, 53(10), 2115-2125 (2012-08-03)
HDL particles may enter atherosclerotic lesions having an acidic intimal fluid. Therefore, we investigated whether acidic pH would affect their structural and functional properties. For this purpose, HDL(2) and HDL(3) subfractions were incubated for various periods of time at different
S Takai et al.
Clinica chimica acta; international journal of clinical chemistry, 265(1), 13-20 (1997-11-14)
A chymostatin-sensitive angiotensin II-generating enzyme was found in human gastroepiploic arteries. The enzyme was purified using heparin affinity and gel filtration columns. The molecular mass of the purified enzyme was 30 kDa, and the optimum pH was between 7.5 and
Ananya Roy et al.
The Journal of biological chemistry, 289(1), 237-250 (2013-11-22)
During infection and tissue damage, virulence factors and alarmins are pro-inflammatory and induce activation of various immune cells including macrophages and mast cells (MCs). Activated MCs instantly release preformed inflammatory mediators, including several proteases. The chymase mouse mast cell protease
Devandir Antonio de Souza et al.
PloS one, 7(7), e40790-e40790 (2012-07-21)
Tumor cells are surrounded by infiltrating inflammatory cells, such as lymphocytes, neutrophils, macrophages, and mast cells. A body of evidence indicates that mast cells are associated with various types of tumors. Although role of mast cells can be directly related
Jacco J de Haan et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(5), G383-G391 (2013-07-03)
Nutritional stimulation of the cholecystokinin-1 receptor (CCK-1R) and nicotinic acetylcholine receptor (nAChR)-mediated vagal reflex was shown to reduce inflammation and preserve intestinal integrity. Mast cells are important early effectors of the innate immune response; therefore modulation of mucosal mast cells
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