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Merck
CN

C7802

Charybdotoxin

≥90% (HPLC), voltage-gated potassium channel blocker, powder

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关于此项目

经验公式（希尔记法）:
C176H277N57O55S7
化学文摘社编号:
95751-30-7
分子量:
4295.89
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD00146378

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产品名称

Charybdotoxin, ≥90% (HPLC)

SMILES string

S1SC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H]5NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)

InChI

1S/C176H277N57O55S7/c1-81(2)58-106-149(263)213-110(62-91-67-191-80-197-91)152(266)215-112(64-127(183)246)156(270)231-135(85(8)240)170(284)219-114(69-234)157(271)200-95(36-25-54-192-174(185)186)138(252)196-68-130(249)199-96(32-17-21-50-177)139(253)222-120-75-291-295-79-124(226-159(273)116(71-236)218-167(281)132(82(3)4)228-155(269)113(65-128(184)247)216-169(283)134(84(7)239)230-154(268)108(59-88-28-13-12-14-29-88)210-145(259)102-44-47-129(248)198-102)166(280)232-137(87(10)242)172(286)233-136(86(9)241)171(285)220-115(70-235)158(272)204-98(34-19-23-52-179)141(255)206-104(45-48-131(250)251)147(261)225-122-77-292-290-74-119(223-143(257)99(35-20-24-53-180)201-140(254)97(33-18-22-51-178)203-153(267)111(63-126(182)245)214-148(262)105(49-57-289-11)208-162(120)276)161(275)205-101(38-27-56-194-176(189)190)144(258)224-121(164(278)211-107(60-89-39-41-92(243)42-40-89)150(264)221-118(73-238)173(287)288)76-293-294-78-123(163(277)207-103(43-46-125(181)244)146(260)202-100(142(256)209-106)37-26-55-193-175(187)188)227-168(282)133(83(5)6)229-160(274)117(72-237)217-151(265)109(212-165(122)279)61-90-66-195-94-31-16-15-30-93(90)94/h12-16,28-31,39-42,66-67,80-87,95-124,132-137,195,234-243H,17-27,32-38,43-65,68-79,177-180H2,1-11H3,(H2,181,244)(H2,182,245)(H2,183,246)(H2,184,247)(H,191,197)(H,196,252)(H,198,248)(H,199,249)(H,200,271)(H,201,254)(H,202,260)(H,203,267)(H,204,272)(H,205,275)(H,206,255)(H,207,277)(H,208,276)(H,209,256)(H,210,259)(H,211,278)(H,212,279)(H,213,263)(H,214,262)(H,215,266)(H,216,283)(H,217,265)(H,218,281)(H,219,284)(H,220,285)(H,221,264)(H,222,253)(H,223,257)(H,224,258)(H,225,261)(H,226,273)(H,227,282)(H,228,269)(H,229,274)(H,230,268)(H,231,270)(H,232,280)(H,233,286)(H,250,251)(H,287,288)(H4,185,186,192)(H4,187,188,193)(H4,189,190,194)/t84-,85-,86-,87-,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,132+,133+,134+,135+,136+,137+/m1/s1

InChI key

CNVQLPPZGABUCM-LIGYZCPXSA-N

assay

≥90% (HPLC)

form

powder

storage temp.

−20°C

Quality Level

200

Gene Information

human ... KCNA3(3738)
mouse ... KCNA3(16491)
rat ... KCNA3(29731)

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相关类别

Application

Charybdotoxin has been used:
  • in the inhibition of endothelium-derived hyperpolarizing factor responses
  • in electrophysiological studies, as calcium channel blockers
  • as a transport inhibitor

Biochem/physiol Actions

Charybdotoxin (ChTX) is a scorpion venom, which blocks a voltage-gated potassium channel, by binding to the extracellular loop of the potassium channel.
High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Kv1.3 channel blocker.
Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.

Other Notes

Peptide found in the venom of the scorpion Leiurus quinquestriatus.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

高风险级别生物产品--毒素类产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000315432
0000315432
0000291660
0000291660
0000372897

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J M Doughty et al.
The American journal of physiology, 276(3 Pt 2), H1107-H1112 (1999-03-10)
In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a combination of apamin and charybdotoxin (ChTX). The site of action of these toxins has not been established. We compared the effects of ChTX and apamin applied selectively to
Cultured heart cells from oyster: an experimental approach for evaluation of the toxicity of the marine pollutant tributyltin
Droguet M, et al.
Aquatic Living Resources, 25(2), 185-194 (2012)
Transepithelial impedance analysis of chloride secretion.
Ashvani K Singh et al.
Methods in molecular medicine, 70, 129-142 (2002-03-29)
Solution structure of extracellular loop of human beta4 subunit of BK channel and its biological implication on ChTX sensitivity
Wang Y, et al.
Scientific Reports, 8(1), 4571-4571 (2018)
M L Garcia et al.
The American journal of physiology, 269(1 Pt 1), C1-10 (1995-07-01)
Over the last few years, a considerable amount of information has been obtained regarding K+ channels. Different areas of research have contributed to knowledge in this field. Charybdotoxin (ChTX), a 37-amino acid peptide isolated from venom of the scorpion Leiurus
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Product Information Sheet - C7802

Product Information Sheet

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