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Merck
CN
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文件

C6645

Sigma-Aldrich

胞嘧啶β-D-呋喃阿拉伯糖苷 盐酸盐

crystalline

别名:

1-(β-D-呋喃阿拉伯糖苷)­胞嘧啶 盐酸盐, Ara-C 盐酸盐, 胞嘧啶阿拉伯糖苷 盐酸盐, 阿拉伯糖胞嘧啶 盐酸盐, 阿糖胞嘧啶 盐酸盐, 阿糖胞苷 盐酸盐

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About This Item

经验公式（希尔记法）:
C9H13N3O5 · HCl
CAS号:
69-74-9
分子量:
279.68
EC 号:
200-713-9
MDL编号:
MFCD00012839
UNSPSC代码:
12352202
PubChem化学物质编号:
24278329
NACRES:
NA.77

生物来源

synthetic (inorganic)

质量水平

200

检测方案

≥99% (HPLC)

形式

crystalline

mp

197-198 °C (lit.)

储存温度

2-8°C

SMILES字符串

Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O

InChI

1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1

InChI key

KCURWTAZOZXKSJ-JBMRGDGGSA-N

基因信息

human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)

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相关类别

应用

胞嘧啶 β- D -阿拉伯呋喃糖苷盐酸盐已用于补充胎牛血清的 Dulbecco改良 eagle 培养基 (FBS-DMEM) 和 B27/neurobasal-A 培养基 ，以抑制神经胶质细胞的生长。它也被用于抑制胚胎脊髓神经元的星形胶质细胞增生。

生化/生理作用

Ara-C 被磷酸化为 Ara-CTP 并掺入 DNA。通过与拓扑异构酶 Ⅰ 形成剪切复合物来抑制 DNA 复制并导致 DNA 片段化，最终通过 PKC 信号通路诱导细胞凋亡。不抑制 RNA 合成。抗白血病药物。

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险分类

Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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