C5865
CD437
≥98% (HPLC), retinoic acid receptor (RAR)γ-selective agonist, solid
别名:
6- [3-（1-金刚烷基）-4-羟苯基] -2-萘甲酸, AHPN
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关于此项目
经验公式（希尔记法）:
C27H26O3
化学文摘社编号:
分子量:
398.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
CD437, ≥98% (HPLC), solid
SMILES string
OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5
InChI key
LDGIHZJOIQSHPB-UHFFFAOYSA-N
InChI
1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
assay
≥98% (HPLC)
form
solid
impurities
~0.5 mol/mol water
color
yellow
mp
271.6-276 °C
solubility
DMSO: >10 mg/mL
H2O: insoluble
storage temp.
−20°C
Quality Level
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916)
Biochem/physiol Actions
CD437 是视黄酸受体（RAR）γ-选择性激动剂，γ-选择性视黄酸；凋亡的有效诱导剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Takaharu Asano et al.
Frontiers in cardiovascular medicine, 9, 842641-842641 (2022-04-12)
Conventional drug screening methods search for a limited number of small molecules that directly interact with the target protein. This process can be slow, cumbersome and has driven the need for developing new drug screening approaches to counter rapidly emerging
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis.
Fang Tan et al.
Frontiers in microbiology, 10, 2301-2301 (2019-10-28)
Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound
Almudena Bosch et al.
Breast cancer research : BCR, 14(4), R121-R121 (2012-08-28)
Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found to play specific functions in the expansion and
Leeanna El-Houjeiri et al.
Molecular cancer therapeutics, 16(10), 2047-2057 (2017-06-18)
Acute myeloid leukemia (AML) is one of the most frequent types of blood malignancies. It is a complex disorder of undifferentiated hematopoietic progenitor cells. The majority of patients generally respond to intensive therapy. Nevertheless, relapse is the major cause of
Liyue Zhang et al.
Journal of molecular signaling, 5, 12-12 (2010-08-14)
A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their
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