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Merck
CN
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文件

C5429

Sigma-Aldrich

Z-精氨酸-精氨酸-7-酰氨基-4-甲基香豆素 盐酸盐

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别名:
Z-RR-AMC
经验公式（希尔记法）:
C30H39N9O6
CAS号:
136132-67-7
分子量:
621.69
MDL编号:
MFCD00133576
UNSPSC代码:
12352209
PubChem化学物质编号:
24892784
NACRES:
NA.32

形式

powder

质量水平

200

杂质

~4% isopropanol

储存温度

−20°C

SMILES字符串

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H

InChI key

HLSNWWKWVKPXKI-UHFFFAOYSA-N

基因信息

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

Amino Acid Sequence

Z-Arg-Arg-AMC

应用

Z-精氨酸-精氨酸-7-氨基-4-甲基香豆素盐酸盐已用于：
  • 粪便提取物中蛋白酶酶谱分析中的组织蛋白酶B底物。
  • 组织蛋白酶B活性测定。
  • 作为荧光肽底物用于测定基质金属蛋白酶的活性。

底物

组织蛋白酶B的荧光底物。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Tomas Erban et al.
Frontiers in physiology, 7, 53-53 (2016-03-05)
Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate
Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury
Cortes A L, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 102-114 (2018)
Miguel G Ximénez-Embún et al.
PloS one, 11(1), e0145275-e0145275 (2016-01-07)
Climate change will bring more drought periods that will have an impact on the irrigation practices of some crops like tomato, from standard water regime to deficit irrigation. This will promote changes in plant metabolism and alter their interactions with
Pavel Kielkowski et al.
Nature communications, 11(1), 517-517 (2020-01-26)
Posttranslational modification (PTM) of proteins represents an important cellular mechanism for controlling diverse functions such as signalling, localisation or protein-protein interactions. AMPylation (also termed adenylylation) has recently been discovered as a prevalent PTM for regulating protein activity. In human cells
Aline L Cortes et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(1), 102-114 (2017-10-11)
Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Doxycycline (Dc) belongs to the tetracycline-class of antibiotics with demonstrated beneficial molecular effects in the brain and heart, mainly through matrix metalloproteinases inhibition (MMP). However, Dc protection of
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Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

组织蛋白酶B的酶活检测

组织蛋白酶B是具有广泛特异性的溶酶体半胱氨酸蛋白酶。本方案采用Nα–CBZ–Arg–Arg–7–酰胺基-4-甲基香豆素作为荧光检测组织蛋白酶B活性的底物。

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