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C5240

Anti-phospho-c-Abl (pTyr⁴¹²) antibody produced in rabbit

Name: Anti-phospho-c-Abl (pTyr<SUP>412</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 3096.05 CNY
Availability: InStock

affinity isolated antibody, buffered aqueous solution

别名:

Anti-ABL, Anti-BCR-ABL, Anti-CHDSKM, Anti-JTK7, Anti-bcr/abl, Anti-c-ABL, Anti-c-ABL1, Anti-p150, Anti-v-abl

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20 μG

CN¥3,096.05

50 μG

CN¥5,521.21

CN¥3,096.05

预计发货时间June 27, 2025详情

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选择尺寸

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20 μG

CN¥3,096.05

50 μG

CN¥5,521.21

About This Item

MDL编号:

MFCD06798483

UNSPSC代码:

12352203

NACRES:

NA.44

CN¥3,096.05

预计发货时间June 27, 2025详情

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此商品	EHU067331	EHU087831	EHU088431
EHU114811 MISSION^® esiRNA	EHU067331 MISSION^® esiRNA	EHU087831 MISSION^® esiRNA	EHU088431 MISSION^® esiRNA
esiRNA cDNA target sequence CAGCGCATATCATCTCATGGGGTCCAGAGTGGAGTCCAGGCTTCTCTGAAACCAGGGCTGAGCATATTTCCATAGCCAAGGAGGTGGGACTCCCTGGAGCTATCTGTGGTCTTAGGGAAGGATCCAGACATACACGGCTTTGGGGTACAAGCTGTGATCACTGATCAATAAATTATCTCTAGATTGGTCCTTGTGAGGGGAGTTTTAAGAATCCAGAACATCTTGCTCTTGATCAGCACATCCAAAAACACCAAGACAAACATCCAGTGGAGCAGAACCTCTCCTGCCTCGGGAGTTCTGACCGGGTTCCCCAGCAGGGTGTTAAGCCTCTGTCTCTGGCCCTACCAGCATCCAGGTTCCACTTTCCTAGGAGAGAGTGGAGATGGGAAGACAGGGAAAGGAAGG	esiRNA cDNA target sequence CACAAGGACCACCAGTACCAGTTCTTAGAGGATGCAGTGAGGAACCAGCGCAAGCTCCTGGCCTCACTGGTGAAGCGCCTTGGGGACAAACATGCAACATTGCAGAAGAGCACCAAGGAGGTTCGCAGCTCAATCCGCCAGGTGTCTGACGTACAGAAGCGTGTGCAAGTGGATGTCAAGATGGCCATCCTGCAGATCATGAAGGAGCTGAATAAGCGGGGCCGTGTGCTGGTCAATGATGCCCAGAAGGTGACTGAGGGGCAGCAGGAGCGCCTGGAGCGGCAGCACTGGACCATGACCAAGATCCAGAAGCACCAGGAGCACATTCTGCGCTTTGCCTCTTGGGCTCTGGAGAGTGACAACAACACAGCCCTTTTGCTTTCTAAGAAGTTGATCTACTTCCAGCTGCACCG	esiRNA cDNA target sequence TCATGGATGCTCTGGATGAGAGAGCCAAGGTGCTGCATGAGGACAAGCAGACCCGGGAGCAGCTGCATAGCATCAGCGACTCTGTGTTGTTTCTGCAGGAATTTGGTGCATTGATGAGCAATTACTCTCTCCCCCCACCCCTGCCCACCTATCATGTCCTGCTGGAGGGGGAGGGCCTGGGACAGTCACTAGGCAACTTCAAGGACGACCTGCTCAATGTATGCATGCGCCACGTTGAGAAGATGTGCAAGGCGGACCTGAGCCGTAACTTCATTGAGAGGAACCACATGGAGAACGGTGGTGACCATCGCTATGTGAACAACTACACGAACAGCTTCGGGGGTGAGTGGAGTGCACCGGACACCATGAAGAGATACTCCATGTACCTGACACCCAAAGGTGGGGTCCGGACATCATACCAGCCCTCGTC	esiRNA cDNA target sequence ATGAACAATATAAAGCACTTAAAGGAAGAGGATGATTTCTTCCAGCTTTTCCACACTCTCTTTATGCGCAGGAACAAACAGCTGTTGAGTGAGCTGCTATGACTTTGGTAGAGAGGTGCAATATGTTTTTTGAACCAGCTATAAAAGAAATTAAGAGGTACATGTGAGGGTAGAAACAAATATCAAGGATGAGAATGGCACTGGCTGTCCCATATGGTATCCAGGAGCCACCAATGTCTGTTGAGTACTTCATACATGCCTAGTCTGAATTGAGATGTGCTCAATGTATAAAATATATACCAGATTTCAAATACCTACTTCAAAAAATAATGTAAAATATCTCACTAATAACTTTTCCTTTGTGTATTGCAATGATAATATGTTGGCTCTATTGGATTAA
product line MISSION^®	product line MISSION^®	product line MISSION^®	product line MISSION^®
Ensembl \| human accession no. ENSG00000137313	Ensembl \| human accession no. ENSG00000130726	Ensembl \| human accession no. ENSG00000137699	Ensembl \| human accession no. ENSG00000121236
NCBI accession no. NM_003449	NCBI accession no. NM_005762	NCBI accession no. NM_012101	NCBI accession no. NM_001003819
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

一般描述

c-Abl is a proto-oncogene of the Src family of non-receptor tyrosine kinases. It is a cellular homologue of Ablelson murine leukemia virus, and is implicated in many important cellular processes and tumorigenesis. In mammalian cells, c-Abl is expressed ubiquitously but its localization within a cell depends on the cell type and the environmental signals. c-Abl has distinct SH2 and SH3 domains that indicate high affinity for tyrosine and proline residues. Complete activation of c-Abl requires phosphorylation at two tyrosine residues at 412 and 245. Some of the downstream targets of c-Abl identified are ATM, DNA-PK, BRCA1, and transcription factors p73 and RFX1. Several reports implicate c-Abl in Apoptosis, DNA repair, T cell development and neuronal development.
Anti-phospho-c-Abl [pTyr⁴¹²] specifically recognizes c-Abl phosphorylated at tyrosine 412 (~140-150 kDa). The antibody detects human c-Abl. Mouse c-Abl (100% homology) and rat c-Abl is expected to cross react.

免疫原

synthetic phosphopeptide derived from the region of c-Abl that contains tyrosine 412.

应用

Anti-phospho-c-Abl [pTyr⁴¹²] may be used at a working dilultion of 1:1000 for immunoblotting in fibroblasts transfected with oncogenic δSH3-Abl. It may be used for immunodetection in HEK293 cells, cerebellar granule neuron cultures and primary cells from rat hippocampus. The antibody has been reported for immunoprecipitaion applications in HEK293T cells.

外形

Solution in Dulbecco′s phosphate buffered saline, pH 7.3, 50% glycerol,with 1 mg/mL BSA and 0.05% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

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Not applicable

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Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling.

Fabiola Rojas et al.

Frontiers in cellular neuroscience, 9, 203-203 (2015-06-25)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which pathogenesis and death of motor neurons are triggered by non-cell-autonomous mechanisms. We showed earlier that exposing primary rat spinal cord cultures to conditioned media derived from primary mouse astrocyte

Abl tyrosine kinases in T-cell signaling.

Jing Jin Gu et al.

Immunological reviews, 228(1), 170-183 (2009-03-18)

Stimulation of the T-cell antigen receptor (TCR) leads to the activation of signaling pathways that are essential for T-cell development and the response of mature T cells to antigens. The TCR has no intrinsic catalytic activity, but TCR engagement results

Controlling Abl: auto-inhibition and co-inhibition?

Jean Y J Wang

Nature cell biology, 6(1), 3-7 (2004-01-06)

Auto-inhibition describes the capacity of proteins to adopt a self-imposed latent conformation. Recently, a crystal structure of the Abl tyrosine kinase has revealed its ability to auto-inhibit. However, a separate body of work suggests that other cellular proteins also inhibit

c-Abl: activation and nuclear targets.

Y Shaul

Cell death and differentiation, 7(1), 10-16 (2000-03-14)

The c-Abl tyrosine kinase and its transforming variants have been implicated in tumorigenesis and in many important cellular processes. c-Abl is localized in the nucleus and the cytoplasm, where it plays distinct roles. The effects of c-Abl are mediated by

The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death.

Lei Xiao et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(26), 9611-9619 (2011-07-01)

Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. The protein kinase MST1 (mammalian Ste20-like kinase 1) plays a major role in oxidative stress-induced cell death in primary

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Anti-phospho-c-Abl (pTyr⁴¹²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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