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单克隆抗-细胞周期蛋白A 小鼠抗

clone CY-A1, ascites fluid

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

CY-A1, monoclonal

分子量

antigen 60 kDa

包含

15 mM sodium azide

种属反应性

mouse, human, monkey, bovine

技术

immunocytochemistry: suitable
microarray: suitable
western blot: 1:1,000 using a mouse NIH 3T3 cell extract

同位素/亚型

IgG2a

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... CCNA2(890)
mouse ... Ccna2(12428)

相关类别

一般描述

细胞周期蛋白 A 是 S 期的核蛋白,它与 cdk2 和 cdc2 结合。与细胞周期蛋白 A 特异性反应的单克隆抗体的可用性使得细胞周期蛋白 A 的亚细胞检测和定位,以及细胞周期蛋白水平的相对差异(作为细胞周期阶段的功能)的测量成为可能。

特异性

该抗体识别牛细胞周期蛋白 A 氨基酸 162-433 中存在的表位。未发现与其他细胞周期蛋白(细胞周期蛋白 B、D 或 E)有交叉反应。

免疫原

重组牛细胞周期蛋白 A。

应用

小鼠单克隆抗 Cyclin A 抗体适用于:
  • 免疫细胞化学
  • 微阵列
  • 蛋白质印迹(使用小鼠 NIH 3T3 细胞提取物,1:1,000 稀释)

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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J E Dazard et al.
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p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. The role of the p53/MDM2 regulatory loop upon genotoxic
Qing-Hua Zhang et al.
The Journal of cell biology, 216(10), 3133-3143 (2017-08-19)
Cyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in prometaphase within minutes of nuclear envelope breakdown. The role of cyclin A2 in female meiosis and its dynamics during the transition
Emma L Hesketh et al.
Cell cycle (Georgetown, Tex.), 14(3), 333-341 (2015-02-07)
The minichromosome maintenance complex (MCM2-7) is the putative DNA helicase in eukaryotes, and essential for DNA replication. By applying serial extractions to mammalian cells synchronized by release from quiescence, we reveal dynamic changes to the sub-nuclear compartmentalization of MCM2 as
Matthew Hoare et al.
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Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which
T-Y Chen et al.
Oncogenesis, 4, e180-e180 (2015-12-23)
The antitumor drug etoposide (ETO) is widely used in treating several cancers, including adrenocortical tumor (ACT). However, when used at sublethal doses, tumor cells still survive and are more susceptible to the recurring tumor due to centrosome amplification. Here, we

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