生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
rat
技术
western blot: 1:200 using rat brain membranes
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CACNA1I(8911)
rat ... Cacna1i(56827)
一般描述
Calcium channel CaV3.3 (α1I) is a low-voltage-activated T-type calcium channel. CaV3.3 (α1I) transcripts are detected in central nervous system as well as thyroid and adrenal glands.
免疫原
peptide corresponding to amino acid residues 1053-1067 of rat CaV3.3. Homology with other species: human is 14/15 residues identical.
应用
Anti-Calcium Channel CaV3.3 (a1I) antibody produced in rabbit is suitable for western blot at a dilution of 1:200 using rat brain membranes.
生化/生理作用
Calcium channel CaV3.3 (α1I) is involved in neuronal excitability and is particularly recruited during the depolarizing after-potential. It is responsible for generating sustained electrical activity. Sperm specific proteins CatSper1 and CatSper2 interact with Cav3.3 and suppress Cav3.3-evoked T-type calcium channel activity.
外形
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
Edward Perez-Reyes
Physiological reviews, 83(1), 117-161 (2002-12-31)
T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because they can be activated by small depolarizations of the plasma membrane. In many neurons Ca2+ influx through LVA channels triggers low-threshold spikes, which in turn triggers a burst of action
Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.
Di Zhang et al.
The Journal of biological chemistry, 281(31), 22332-22341 (2006-06-03)
Sperm-specific CatSper1 and CatSper2 proteins are critical to sperm-hyperactivated motility and male fertility. Although architecturally resembling voltage-gated ion channels, neither CatSper1 nor CatSper2 alone forms functional ion channels in heterologous expression systems, which may be related to the absence of
Jean Chemin et al.
The Journal of physiology, 540(Pt 1), 3-14 (2002-04-03)
In several types of neurons, firing is an intrinsic property produced by specific classes of ion channels. Low-voltage-activated T-type calcium channels (T-channels), which activate with small membrane depolarizations, can generate burst firing and pacemaker activity. Here we have investigated the
Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.
Zhang, et al.
The Journal of Neuroscience, 42, 6487-6505 (2023)
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