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Merck
CN
所有图片(2)

主要文件

C4522

Sigma-Aldrich

西咪替丁

别名:

SKF-92334

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5 G
¥1,135.44
10 G
¥1,592.51
25 G
¥3,483.43

¥1,135.44


预计发货时间2025年4月27日详情


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选择尺寸

变更视图
5 G
¥1,135.44
10 G
¥1,592.51
25 G
¥3,483.43

About This Item

经验公式(希尔记法):
C10H16N6S
CAS号:
分子量:
252.34
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

¥1,135.44


预计发货时间2025年4月27日详情


获取大包装报价

表单

powder

质量水平

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES字符串

CN\C(NC#N)=N\CCSCc1nc[nH]c1C

InChI

1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

InChI key

AQIXAKUUQRKLND-UHFFFAOYSA-N

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此商品
PHR1075SML1493E2535
西咪替丁

C4522

西咪替丁

form

powder

form

-

form

powder

form

powder

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

originator

GlaxoSmithKline

originator

-

originator

-

originator

Abbott

Gene Information

human ... ABCB1(5243), CYP1A2(1544), CYP3A4(1576), HRH2(3274), SLC9A2(6549), SLC9A5(6553)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Slc9a1(24782), Slc9a3(24784), Slc9a5(192215)

Gene Information

human ... HRH2(3274)

Gene Information

-

Gene Information

human ... AGTR1(185)

生化/生理作用

H2组胺受体拮抗剂;I1咪唑啉受体激动剂;抗溃疡剂。通过抑制内皮细胞表面上E-选择蛋白的表达来阻断癌症转移,从而阻断肿瘤细胞的粘附。

特点和优势

该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

  • 技术规格说明书

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    K Kobayashi et al.
    Cancer research, 60(14), 3978-3984 (2000-08-05)
    Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated. In this report, we have demonstrated for the first time that cimetidine
    Huan Yang et al.
    Molecular medicine (Cambridge, Mass.), 28(1), 57-57 (2022-05-17)
    Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical
    Sarit Pal et al.
    Biology open, 11(7) (2022-07-02)
    Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and tissue types.
    H van der Goot et al.
    European journal of medicinal chemistry, 35(1), 5-20 (2000-03-25)
    In this review the histaminergic ligands for the histamine H(1), H(2) and H(3) receptors, which are currently used as tools in pharmacological studies, are described. To study interactions with the histamine H(1) receptor, the H(1) agonist 2-aminoethylthiazole has long since
    Hiroki Shimizu et al.
    ChemMedChem, 17(16), e202200204-e202200204 (2022-06-14)
    We synthesized and experimentally tested the passive permeability of more than thirty tetrapeptides mimicking the N-terminus of the pro-apoptotic protein Smac (Second mitochondria-derived activator of caspases). Each peptide bore one or two unnatural Hydrogen Bond Acceptor-bearing Amino Acid (HBA-AA) residues

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