C3909
D-环丝氨酸
synthetic
别名:
(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮
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选择尺寸
关于此项目
经验公式（希尔记法）:
C3H6N2O2
化学文摘社编号:
分子量:
102.09
UNSPSC Code:
12352209
NACRES:
NA.28
PubChem Substance ID:
EC Number:
200-688-4
Beilstein/REAXYS Number:
80798
MDL number:
产品名称
D-环丝氨酸, synthetic
InChI key
DYDCUQKUCUHJBH-UWTATZPHSA-N
InChI
1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
SMILES string
N[C@@H]1CONC1=O
biological source
synthetic
form
powder
mp
147 °C (dec.) (lit.)
solubility
water: 50 mg/mL, clear, colorless to light yellow
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mode of action
cell wall synthesis | interferes
storage temp.
−20°C
Quality Level
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
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Application
D-cycloserine has been used to inhibit serine hydroxymethyltransferase.
General description
Chemical structure: amino acid derivatives
Biochem/physiol Actions
作用方式：抑制细胞壁生物合成（D-Ala 肽键形成）。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂；抗革兰氏阴性细菌的抗生素。
干预方式：D-Ala转运干预。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂；抗革兰氏阴性细菌的抗生素。
干预方式：D-Ala转运干预。
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Kathryn D Baker et al.
Learning & memory (Cold Spring Harbor, N.Y.), 19(10), 461-469 (2012-09-18)
The NMDA receptor partial agonist d-cycloserine (DCS) enhances the extinction of learned fear in rats and exposure therapy in humans with anxiety disorders. Despite these benefits, little is known about the mechanisms by which DCS promotes the loss of fear.
Bram Vervliet
Acta psychologica, 127(3), 601-613 (2007-08-21)
This review addresses the effects of the cognitive enhancer D-cycloserine (DCS) on the memory processes that occur in conditioned fear extinction, which is the experimental model for exposure techniques to reduce clinical anxiety. All reported rat studies show an enhanced
Ram Maharjan et al.
Molecular biology and evolution, 32(2), 380-391 (2014-11-13)
Evolutionary innovations are dependent on mutations. Mutation rates are increased by adverse conditions in the laboratory, but there is no evidence that stressful environments that do not directly impact on DNA leave a mutational imprint on extant genomes. Mutational spectra
Marta Portero-Tresserra et al.
Neurobiology of learning and memory, 100, 1-11 (2012-12-04)
It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or
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