生物来源
human
质量水平
重组
expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
形式
solution
比活
≥4 units/pmol enzyme
分子量
45-60 kDa
包装
vial of 0.5 nmol
技术
activity assay: suitable
溶解性
water: soluble
适用性
suitable for molecular biology
UniProt登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... CYP1A1(1543)
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生化/生理作用
CYP1A1亚型催化乙氧基试卤灵的7-脱乙基。
细胞色素 P450 是一个具有异质性的同工酶家族，其主要功能是氧化小分子，既是中间代谢（如脂肪酸）的功能，也是对外源化合物（药物或毒素）解毒的功能。一些亚型具有较窄的底物特异性，而另一些则是替代的。
外形
100 mM 磷酸钾缓冲液，pH 7.4溶液。
制备说明
含人CYP1A1和重组人NADPH-P450还原酶的微粒体。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Tomas Erban et al.
Biomedical chromatography : BMC, 26(9), 1062-1065 (2011-11-29)
A 96-well microplate-based HPLC endpoint assay is described for the determination of NADPH-cytochrome P450 reductase (CPR) activity. Novel sampling of NADPH into microplates was optimized. Separation was performed on a Zorbax Eclipse XDB-C₁₈ analytical 4.6 × 150 mm, 5 µm column. To validate the
Moritz Walter et al.
Toxicology in vitro : an international journal published in association with BIBRA, 59, 215-220 (2019-04-21)
Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate
David Stucki et al.
Archives of biochemistry and biophysics, 687, 108383-108383 (2020-04-27)
Intracellular carbon monoxide (CO) is a gaseous signaling molecule and is generated enzymatically by heme oxygenases upon degradation of heme to billiverdin. Target structures for intracellular produced CO are heme proteins including cytochrome c oxidase of the respiratory chain, cytochrome
D P Bofinger et al.
Toxicological sciences : an official journal of the Society of Toxicology, 62(2), 299-314 (2001-07-14)
Endometriosis is a debilitating disease estimated to affect 10% of reproductive-age women and characterized by the growth of endometrial tissue outside of the uterus. The present study characterizes a human endometrial explant culture model for studying the direct effects of
Morgane Modoux et al.
Gut microbes, 14(1), 2105637-2105637 (2022-07-28)
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood. This study investigates the effect of
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