C221
羧基-PTIO 钾盐
synthetic (organic), ≥98% (TLC), NO scavenger, powder
别名:
2-（4-羧基苯基）-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物 钾盐, 2-（4-羧基苯基）-4,5-二氢-4,4,5,5-四甲基-1H-咪唑-1-基氧基-3-氧化物 钾盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C14H16KN2O4
化学文摘社编号:
分子量:
315.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
羧基-PTIO 钾盐,
SMILES string
[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
InChI
1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
InChI key
VYEUQMVIGXFZQU-UHFFFAOYSA-M
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
mp
>270 °C
solubility
H2O: 100 mg/mL
DMSO: soluble (lit.)(lit.)
methanol: soluble (lit.)(lit.)
storage temp.
2-8°C
Quality Level
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Application
羧基-PTIO钾盐通过检查反应混合物中羟基自由基或硝酸的生成情况，确定反应混合物中一氧化氮的生成情况。还可添加至神经元，分析其对葡萄糖/氧气/血清剥夺（GOSD）状态的影响（4）
Biochem/physiol Actions
其与一氧化氮反应可形成羧基-PTI衍生物，产物可进一步抑制一氧化氮合成酶的活性。
羧基-PTIO可以与一氧化氮（NO）快速反应生成二氧化氮（NO2）。 可用于预防 体内脂多糖刺激引起的低血压和内毒素性休克。羧基-PTIO还可以阻断 体外 NO刺激造成的血管松弛。
General description
2-（4-羧苯基）-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物（羧基-PTIO）主要被认为是一氧化氮（NO）清除剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Xinyi Zhu et al.
Applied and environmental microbiology, 85(3) (2018-11-28)
While both iron and nitric oxide (NO) are redox-active environmental signals shown to regulate biofilm development, their interaction and roles in regulating biofilms have not been fully elucidated. In this study, exposure of Pseudomonas aeruginosa biofilms to exogenous NO inhibited
Raymond N Allan et al.
Nitric oxide : biology and chemistry, 65, 43-49 (2017-02-27)
Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections. Novel therapeutic strategies are needed to improve anti-biofilm efficacy and support reduction in antibiotic use. Treatment
Nitric oxide scavenger carboxy-PTIO potentiates the inhibition of dopamine uptake by nitric oxide donors
Cao B J and Reith M EA
European Journal of Pharmacology, 448(1), 27-30 (2002)
Megumi Hada et al.
International journal of molecular sciences, 20(18) (2019-09-07)
Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human
Interference of carboxy-PTIO with nitric oxide-and peroxynitrite-mediated reactions
Pfeiffer S, et al.
Free Radical Biology & Medicine, 22(5), 787-794 (1997)
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