推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
mouse, rat
技术
immunocytochemistry: 1:30-1:150
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:100-1:200
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CACNA1D(776)
mouse ... Cacna1d(12289)
rat ... Cacna1d(29716)
免疫原
synthetic peptide corresponding to amino acids 859-875 of rat α1D (Accession P27732). This epitope is highly conserved in human and hamster.
应用
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:
- immunocytochemistry at a dilution of 1:30-1:150
- immunoprecipitation
- western blot (chemiluminescent) at a dilution of 1:100-1:200
生化/生理作用
Cav1.3 also known as the calcium channel, voltage-dependent, L type, α1D subunit (CACNA1D), is a human gene. It responds more sensitively to depolarization than those of Cav1.2 or Cav3.1. Cav1.3 is required for proper hearing as well as sinoatrial node and brain function. It undergoes extensive alternative splicing. Alternative splicing in the C terminus and drastically modifies gating properties of the channel. The L-type calcium channel Cav1.3 is important in human glucose-induced insulin secretion and common variants in CACNA1D may contribute to type 2 diabetes.
外形
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
含少量动物源组分生物产品
Hua Huang et al.
Molecular pharmacology, 84(4), 643-653 (2013-08-09)
The transcripts of L-type voltage-gated calcium channels (CaV) 1.3 undergo extensive alternative splicing. Alternative splicing, particularly in the C terminus, drastically modifies gating properties of the channel. However, little is known about whether alternative splicing could modulate the pharmacologic properties
T M Reinbothe et al.
Diabetologia, 56(2), 340-349 (2012-12-12)
Voltage-gated calcium channels of the L-type have been shown to be essential for rodent pancreatic beta cell function, but data about their presence and regulation in humans are incomplete. We therefore sought to elucidate which L-type channel isoform is functionally
Jan Salomonsen et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8668-8673 (2005-06-09)
CD1 molecules play an important role in the immune system, presenting lipid-containing antigens to T and NKT cells. CD1 genes have long been thought to be as ancient as MHC class I and II genes, based on various arguments, but
Andreas Lieb et al.
Biophysical journal, 106(7), 1467-1475 (2014-04-08)
Activity of voltage-gated Cav1.3 L-type Ca(2+) channels is required for proper hearing as well as sinoatrial node and brain function. This critically depends on their negative activation voltage range, which is further fine-tuned by alternative splicing. Shorter variants miss a
Ling Lu et al.
The Journal of biological chemistry, 290(8), 4663-4676 (2014-12-30)
Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific
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