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C160

CGP-42112A

Name: CGP-42112A
Brand: SIGMA

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

别名:

N_α-Nicotinoyl-Tyr-(N_α-Cbz-Arg)-Lys-His-Pro-Ile

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关于此项目

经验公式（希尔记法）:

C₅₂H₆₉N₁₃O₁₁

化学文摘社编号:

127060-75-7

分子量:

1052.18

NACRES:

NA.77

PubChem Substance ID:

24892424

UNSPSC Code:

12352200

MDL number:

MFCD00133611

Beilstein/REAXYS Number:

8184948

Assay:

≥95%

Form:

solid

Quality level:

200

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属性

产品名称

CGP-42112A, ≥95%, synthetic, solid

biological source

synthetic

Quality Level

200

assay

≥95%

form

solid

color

white

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

说明

Application

CGP-42112A has been used:

in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000511932

0000484342

0000492066

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Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.

C Sumners et al.

Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)

Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old

Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye.

Anu Vaajanen et al.

Investigative ophthalmology & visual science, 49(6), 2557-2562 (2008-01-29)

In the present study the effects of exogenous angiotensin II and its breakdown metabolite angiotensin (1-7) on the intraocular pressure (IOP) and on aqueous humor dynamics in normotensive rabbit eye were evaluated. Male New Zealand White rabbits with normal IOP

Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats.

Nancy J Hong et al.

Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)

NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via

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