登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式(希尔记法):
C32H43FN6O10 · xC2HF3O2 · yH2O
化学文摘社编号:
分子量:
690.72 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)/t22-,23-,24-,25-/m0/s1
SMILES string
COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
InChI key
YXRKBEPGVHOXSV-QORCZRPOSA-N
assay
≥90%
form
film
storage condition
desiccated
color
colorless to light brown
solubility
DMSO: 10 mg/mL, clear
shipped in
dry ice
storage temp.
−20°C
Application
A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Maegan L Askew et al.
Frontiers in systems neuroscience, 9, 91-91 (2015-07-01)
This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-β-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the α subtype of estrogen receptor (ERα), catecholamines
Jennifer Simpson et al.
American journal of respiratory and critical care medicine, 201(11), 1358-1371 (2020-02-28)
Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality. Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of death remains unknown.Objectives: To determine whether necroptosis contributes to RSV bronchiolitis pathogenesis via HMGB1 (high mobility group
Masahiro Kawatani et al.
Journal of neurophysiology, 126(6), 1959-1977 (2021-11-04)
Barrington's nucleus (Bar), which controls micturition behavior through downstream projections to the spinal cord, contains two types of projection neurons, BarCRH and BarESR1, that have different functions and target different spinal circuitry. Both types of neurons project to the L6-S1
Shuheng Lin et al.
Nature communications, 8, 16074-16074 (2017-07-19)
Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway. Here we describe an unexpected pro-apoptotic role of Notch3 in regulating tumour angiogenesis independently of the Notch
Wei-Lin Hu et al.
Frontiers in cellular and infection microbiology, 7, 471-471 (2017-12-01)
Leptospirosis is a global zoonotic infectious disease caused by pathogenic
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持