推荐产品
表单
solid
质量水平
颜色
tan
溶解性
H2O: 3.7 mg/mL
aqueous base: unstable
ethanol: soluble
储存温度
2-8°C
SMILES字符串
Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3
InChI
1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
InChI key
WLXGFAVTAAQOFH-UHFFFAOYSA-N
基因信息
human ... DRD1(1812)
应用
氯-APB氢溴酸盐用于药理学刺激D1多巴胺受体，研究其对小鼠脂肪量和肥胖相关蛋白(FTO)缺陷多巴胺D1受体表达的中刺状神经元(D1 MSN)运动反应的影响。
生化/生理作用
氯-APB氢溴酸盐又名SKF 82958，是一种D1多巴胺受体激动剂。D1受体激动剂预防和逆转芬太尼诱导的呼吸抑制，而不损害猫的阿片类镇痛作用。
注意
光敏性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kenneth D Carr et al.
Psychopharmacology, 202(4), 731-743 (2008-10-09)
Previous studies have suggested that chronic food restriction (FR) increases sensitivity of a neural substrate for drug reward. The neuroanatomical site(s) of key neuroadaptations may include nucleus accumbens (NAc) where changes in D-1 dopamine (DA) receptor-mediated cell signaling and gene
Liad Mann et al.
The international journal of neuropsychopharmacology, 11(4), 533-539 (2008-01-22)
Lithium ions' inhibition of adenylyl cyclase (AC) has not been previously studied for the newly discovered AC isoforms. COS7 cells were transfected with each of the nine membrane-bound AC isoforms cDNAs with or without D1- or D2-dopamine receptor cDNA. AC
Peter M Lalley
American journal of physiology. Regulatory, integrative and comparative physiology, 289(1), R45-R51 (2005-02-12)
Opioids depress respiration and decrease chest wall compliance. A previous study in this laboratory showed that dopamine-D(1) receptor (D(1)R) agonists restored phrenic nerve activity after arrest by fentanyl in immobilized, mechanically ventilated cats. The reinstated phrenic nerve rhythm was slower
Stefanie Dedeurwaerdere et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 210-217 (2011-07-12)
Phosphodiesterase 10A (PDE10A) inhibitors have recently been proposed as a new therapy for schizophrenia. The aim of this study was to enhance our understanding of the role of PDE10A inhibitors and potentially identify a clinically useful mechanistic/functional biomarker by using
Neil E Paterson et al.
European journal of pharmacology, 616(1-3), 73-80 (2009-06-06)
Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor activity was dependent on harmaline dose. The first-line clinical essential tremor treatments propranolol, primidone and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门