所有图片(1)
About This Item
经验公式（希尔记法）:
C9H4N4O4
CAS号:
分子量:
232.15
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
yellow
溶解性
DMSO: >10 mg/mL
H2O: insoluble
SMILES字符串
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N
InChI
1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChI key
RPXVIAFEQBNEAX-UHFFFAOYSA-N
基因信息
rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409)
应用
CNQX已用于：
- 作为α-氨基-3-羟基-5-甲基-4-异噁唑丙酸(AMPA)/红藻氨酸阻断剂，研究其对胚胎多能干细胞(pESC)丝状伪足(cytoneme)形成的影响
- 作为谷氨酸阻断剂，降低触角叶中心神经元电流钳记录中的突触输入
- 作为非N-甲基-D-天冬氨酸(NMDA)受体阻断剂，研究其对大鼠心率的影响作用
生化/生理作用
有效的竞争性AMPA/红藻氨酸谷氨酸受体拮抗剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Haiyan Li et al.
Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
Sutirtha Ray et al.
Pain, 160(4), 954-964 (2019-01-03)
Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless
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