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Merck
CN

C1112

CP-55940

>98% (HPLC), cannabinoid receptor agonist, powder

别名:

5-(1,1-二甲基庚基)-2-[5-羟基-2-(3-羟丙基)环己基]苯酚

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关于此项目

经验公式（希尔记法）:
C24H40O3
化学文摘社编号:
83002-04-4
分子量:
376.57
UNSPSC Code:
12352200
PubChem Substance ID:
24278295
NACRES:
NA.77
MDL number:
MFCD00673965
Assay:
>98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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产品名称

CP-55940, >98% (HPLC), powder

SMILES string

CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1

InChI key

YNZFFALZMRAPHQ-SYYKKAFVSA-N

InChI

1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1

assay

>98% (HPLC)

form

powder

optical activity

[α]/D -24 to -30°, c = 0.2 in chloroform-d

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

storage condition

desiccated

solubility

DMSO: 15 mg/mL
H2O: slightly soluble

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CNR1(1268), CNR2(1269)
rat ... Cnr1(25248)

相关类别

Features and Benefits

《受体分类和信号转导》手册的大麻素受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

Application

CP-55940在表达大麻素受体2(CB2)的中国仓鼠卵巢(CHO)中被用作大麻素激动剂。

Biochem/physiol Actions

CP-55940是一种缺乏四氢吡喃环的非经典大麻素(NCC)。CP-55940作为CP-47,497的衍生物，是对映选择性的。基于其两亲性的特征，CP-55940系链在生物膜中的作用有利于大麻素受体的相互作用。Cp-55940属于环己基苯酚类，可调节会导致调节异常（尤其在青春期）的大脑脂质组。它会抑制辣椒素诱发的感受性和脊髓背角神经元的敏化。
CP-55940是一种选择性大麻素受体激动剂。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H336

Hazard Classifications

STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000503780
0000503781
0000503780
0000503781
0000483882

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Pradeep Paudel et al.
Marine drugs, 19(6) (2021-07-03)
Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae. Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major ones and despite a wider biological activity profile, knowledge of the G protein-coupled receptor (GPCR) targets of these phlorotannins
David R Maguire et al.
Psychopharmacology, 235(8), 2357-2365 (2018-06-04)
Cannabinoid receptor agonists such as delta-9-tetrahydrocannabinol (Δ9-THC) enhance the antinociceptive potency of mu opioid receptor agonists such as morphine, indicating that opioid/cannabinoid mixtures might be effective for treating pain. However, such enhancement will be beneficial only if cannabinoids do not
The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940
Xie XQ, et al.
The Journal of Biological Chemistry, 271(18), 10640-10647 (1996)
Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons
Johanek LM and Simone DA
Journal of Neurophysiology, 93(2), 989-997 (2005)
Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains
Leishman E, et al.
Frontiers in Molecular Neuroscience, 11, 436-436 (2018)
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Synthetic Cannabinoid Analysis

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

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