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Merck
CN

C104

Sigma-Aldrich

(±)-CPP

solid

别名:

(±)-3-(2-羧基哌嗪-4-基)丙基-1-膦酸

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About This Item

经验公式(希尔记法):
C8H17N2O5P
分子量:
252.20
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

形式

solid

质量水平

颜色

white

溶解性

H2O: 99.2 mg/mL
ethanol: insoluble

SMILES字符串

OC(=O)C1CN(CCCP(O)(O)=O)CCN1

InChI

1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)

InChI key

CUVGUPIVTLGRGI-UHFFFAOYSA-N

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应用

(±)-CPP可用作非竞争性NMDA受体拮抗剂:
  • 研究其对小鼠血糖的影响作用
  • 用于小鼠大脑切片的电生理记录
  • 用于大鼠海马体锥体神经元的电生理记录

生化/生理作用

4-(3-膦酰丙基)哌嗪-2-羧酸(CPP)是强效、竞争性和选择性的N-甲基-D-天冬氨酸(NMDA)受体拮抗剂。它是2-氨基-7-膦酰庚酸的类似物。CPP具有抗惊厥和镇痛作用。

注意

吸湿

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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