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重组
expressed in insect cells Active recombinant N-terminal His-tagged COX-2 N580A mutant purified from insect cells.
expressed in insect cells
质量水平
方案
≥70% (SDS-PAGE)
表单
aqueous solution
比活
≥8000 units/mg protein
分子量
dimer subunit mol wt 70-74 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PTGS2(5743)
生化/生理作用
COX-2 催化花生四烯酸转化为前列腺素 H 2 （前列腺素、血栓素和前列环素生物合成的第一步）。它是由佛波醇酯，脂多糖和细胞因子诱导的诱导形式的环加氧酶。COX-2 在恶性肿瘤的新生血管中表达上调。非甾体抗炎药 (NSAIDs) 抑制 COX-2 与肿瘤生长减少有关。
其他说明
在 N 端附近标记 6 个残基的组氨酸序列。
单位定义
在 37℃、pH 值为 8 的条件下，一个单位每分钟消耗 1.0 纳摩尔氧气。
外形
80mm Tris溶液，pH 8.0，含0.3 mM DDC、0.01% TWEEN® 20和10%甘油
底物
花生四烯酸的 KM = 6.5 μM。表现出与非标记酶相似的 NSAID 活性和敏感性。
法律信息
TWEEN is a registered trademark of Croda International PLC
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
María J Pérez et al.
Journal of food science, 83(5), 1454-1462 (2018-04-17)
This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This
Masanori Sugimoto et al.
Drug development research, 77(1), 20-28 (2016-01-15)
Preclinical Research This article describes the properties of a novel topical NSAID (Nonsteroidal anti-inflammatory drug) patch, SFPP (S(+)-flurbiprofen plaster), containing the potent cyclooxygenase (COX) inhibitor, S(+)-flurbiprofen (SFP). The present studies were conducted to confirm human COX inhibition and absorption of
Mater H Mahnashi et al.
Evidence-based complementary and alternative medicine : eCAM, 2022, 7921408-7921408 (2022-04-12)
Background. The current study aims to give a scientific origin for employing Habenaria plantaginea Lindl. as a potential candidate against nociception, inflammation, and pyrexia. The pharmacological studies were performed on crude extract and subfractions. In the gas chromatography-mass spectroscopy analysis
Alejandra Moreno et al.
Natural product communications, 10(6), 991-994 (2015-07-23)
Zuccagnia punctata Cav. (Fabaceae) is an Argentine medicinal aromatic shrub (jarilla pispito, puspus, lata and jarilla macho). The chalcones were identified as pigments responsible for the yellow color of the flowers. Hydroethanolic extracts were obtained both from fresh flowers and
Muhammad Saeed Jan et al.
European journal of medicinal chemistry, 186, 111863-111863 (2019-11-20)
In recent years, drug discovery paradigm has been shifted from conventional single target inhibition toward multitarget design concept. In current research, we have reported synthesis, in-vitro, in-vivo and acute toxicity determination of N-substituted pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents. We
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