C0858
环氧化酶 2 人
≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein
别名:
前列腺素H 合成酶 2, 环氧合酶-2
产品名称
环氧化酶 2 人, ≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein
recombinant
expressed in insect cells Active recombinant N-terminal His-tagged COX-2 N580A mutant purified from insect cells.
expressed in insect cells
assay
≥70% (SDS-PAGE)
form
aqueous solution
specific activity
≥8000 units/mg protein
mol wt
dimer subunit mol wt 70-74 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... PTGS2(5743)
Biochem/physiol Actions
COX-2 催化花生四烯酸转化为前列腺素 H 2 （前列腺素、血栓素和前列环素生物合成的第一步）。它是由佛波醇酯，脂多糖和细胞因子诱导的诱导形式的环加氧酶。COX-2 在恶性肿瘤的新生血管中表达上调。非甾体抗炎药 (NSAIDs) 抑制 COX-2 与肿瘤生长减少有关。
General description
花生四烯酸的 KM = 6.5 μM。表现出与非标记酶相似的 NSAID 活性和敏感性。
Other Notes
在 37℃、pH 值为 8 的条件下，一个单位每分钟消耗 1.0 纳摩尔氧气。
在 N 端附近标记 6 个残基的组氨酸序列。
Physical form
80mm Tris溶液，pH 8.0，含0.3 mM DDC、0.01% TWEEN® 20和10%甘油
Legal Information
TWEEN is a registered trademark of Croda International PLC
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
María J Pérez et al.
Journal of food science, 83(5), 1454-1462 (2018-04-17)
This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This
Masanori Sugimoto et al.
Drug development research, 77(1), 20-28 (2016-01-15)
Preclinical Research This article describes the properties of a novel topical NSAID (Nonsteroidal anti-inflammatory drug) patch, SFPP (S(+)-flurbiprofen plaster), containing the potent cyclooxygenase (COX) inhibitor, S(+)-flurbiprofen (SFP). The present studies were conducted to confirm human COX inhibition and absorption of
Mater H Mahnashi et al.
Evidence-based complementary and alternative medicine : eCAM, 2022, 7921408-7921408 (2022-04-12)
Background. The current study aims to give a scientific origin for employing Habenaria plantaginea Lindl. as a potential candidate against nociception, inflammation, and pyrexia. The pharmacological studies were performed on crude extract and subfractions. In the gas chromatography-mass spectroscopy analysis
Alejandra Moreno et al.
Natural product communications, 10(6), 991-994 (2015-07-23)
Zuccagnia punctata Cav. (Fabaceae) is an Argentine medicinal aromatic shrub (jarilla pispito, puspus, lata and jarilla macho). The chalcones were identified as pigments responsible for the yellow color of the flowers. Hydroethanolic extracts were obtained both from fresh flowers and
Muhammad Saeed Jan et al.
European journal of medicinal chemistry, 186, 111863-111863 (2019-11-20)
In recent years, drug discovery paradigm has been shifted from conventional single target inhibition toward multitarget design concept. In current research, we have reported synthesis, in-vitro, in-vivo and acute toxicity determination of N-substituted pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents. We
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持