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C0253

Sigma-Aldrich

苯丁酸氮芥

别名:

4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸

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1 G
CN¥1,153.53
10 G
CN¥7,061.10

CN¥1,153.53

国内现货，预计发货时间April 10, 2025详情

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1 G
CN¥1,153.53
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About This Item

经验公式（希尔记法）:
C14H19Cl2NO2
CAS号:
305-03-3
分子量:
304.21
Beilstein:
999011
EC 号:
206-162-0
MDL编号:
MFCD00021783
UNSPSC代码:
12352200
PubChem化学物质编号:
24278287
NACRES:
NA.77

CN¥1,153.53

国内现货，预计发货时间April 10, 2025详情

获取大包装报价

表单

powder

质量水平

200

储存温度

2-8°C

SMILES字符串

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

基因信息

human ... CYP2D6(1565)

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此商品
C0768PHR1241M2768
Chlorambucil

C0253

Chlorambucil

Cyclophosphamide monohydrate bulk package

C0768

Cyclophosphamide monohydrate

L-Methionine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1241

L-Methionine

DL-Methionine BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

M2768

DL-Methionine

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

Gene Information

human ... CYP2D6(1565)

Gene Information

human ... ALDH1A1(216), ALDH1B1(219)

Gene Information

-

Gene Information

-

应用

苯丁酸氮芥已：
  • 用作烷化剂/化疗剂，以研究其对小鼠淀粉样蛋白形成的抗炎作用[1]
  • 用作阳性对照品，以测定白血病小鼠单核巨噬细胞的细胞毒性[2]
  • 用作腺嘌呤特异性DNA烷基化试剂，以为HeLa S3细胞突变特异性DNA烷基化构建多功能共轭物（8950A-Chb(Cl/OH)）[3]

生化/生理作用

苯丁酸氮芥是一种氮芥烷化剂[4]可用作抗癌药物。[5]苯丁酸氮芥可与细胞膜、RNA、DNA和蛋白质结合。它可通过DNA交联表现出抗炎[1]和抗肿瘤活性。[4]苯丁酸氮芥可通过p53-依赖机制显示对慢性淋巴细胞白血病（CLL）的治疗作用。[4]

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    WXBF4436V
    WXBF3026V
    BCCH8961
    BCCG4515
    BCCD5718

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    Qingyao Shou et al.
    Journal of natural products, 76(7), 1384-1387 (2013-07-16)
    Two novel alkaloids (parvifloranines A and B), possessing an unusual 11-carbon skeleton linked with amino acids, were isolated from Geijera parviflora, an endemic Australian Rutaceae. Their structures were elucidated by extensive spectroscopic measurements including 2D NMR analyses. Parvifloranine A was
    Shmuel Shtrasburg et al.
    Autoimmunity reviews, 12(1), 18-21 (2012-08-11)
    The mainstay of AA amyloidosis prevention and treatment is suppression of inflammation. In the present study we have tried to determine the efficacy of a variety of anti-inflammatory agents at suppressing AA amyloidosis in a mouse model of the disease.
    Takuya Hidaka et al.
    Cell chemical biology, 29(4), 690-695 (2021-08-28)
    Mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases, characterized by abnormal mitochondrial function. Although eliminating mutated mtDNA has potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. Here, we construct
    Shrabani Barman et al.
    Angewandte Chemie (International ed. in English), 55(13), 4194-4198 (2016-02-27)
    Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of
    Palle J Pedersen et al.
    Journal of medicinal chemistry, 52(10), 3408-3415 (2009-05-01)
    The synthesis and biophysical characterization of four prodrug ether phospholipid conjugates are described. The lipids are prepared from the anticancer drug chlorambucil and have C16 and C18 ether chains with phosphatidylcholine or phosphatidylglycerol headgroups. All four prodrugs have the ability
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    DNA损伤和修复

    DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

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