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文件

B8279

Ro-20-1724

Name: Ro-20-1724
Brand: SIGMA

≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor

别名:

Ro 20-1724

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About This Item

经验公式（希尔记法）:

C₁₅H₂₂N₂O₃

CAS号:

29925-17-5

分子量:

278.35

MDL编号:

MFCD00077397

UNSPSC代码:

41106305

PubChem化学物质编号:

24278195

NACRES:

NA.77

product name

4-（3-丁氧基-4-甲氧基苄基）咪唑烷-2-酮, solid

生物来源

synthetic (organic)

质量水平

200

检测方案

≥98% (HPLC)

形式

solid

溶解性

ethanol: 7 mg/mL
H₂O: insoluble

储存温度

room temp

SMILES字符串

CCCCOc1cc(CC2CNC(=O)N2)ccc1OC

InChI

1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

InChI key

PDMUULPVBYQBBK-UHFFFAOYSA-N

基因信息

human ... LITAF(9516) , PDE4B(5142) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
rat ... Pde4a(25638)

应用

4-(3-丁氧基-4-甲氧基苄基)咪唑烷-2-酮已用于：

作为环腺苷单磷酸(cAMP)磷酸二酯酶抑制剂来处理细胞，用于测定细胞内cAMP水平
作为无血清培养基成分
作为磷酸二酯酶抑制剂，研究蛋白酶激活受体-1 (PAR-1)激活对cAMP水平的影响

生化/生理作用

cAMP 磷酸二酯酶的抑制剂。在主动脉的血管平滑肌中的 IC₅₀ 值为 33 μM 。

特点和优势

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose

Bodrato N, et al.

The Journal of biological chemistry, 284(22), 14777-14787 (2009)

Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose.

Nicoletta Bodrato et al.

The Journal of biological chemistry, 284(22), 14777-14787 (2009-03-31)

Abscisic acid (ABA) is a phytohormone regulating important functions in higher plants, notably responses to abiotic stress. Recently, chemical or physical stimulation of human granulocytes was shown to induce production and release of endogenous ABA, which activates specific cell functions.

Protease-activated receptor-1 stimulates Ca2+-dependent Cl- secretion in human intestinal epithelial cells

Buresi MC, et al.

American Journal of Physiology: Gastrointestinal and Liver Physiology, 281(2), G323-G332 (2001)

Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster

Chen W, et al.

Insect Biochemistry and Molecular Biology, 43(9), 809-819 (2013)

GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.

A Richard Rutter et al.

The Journal of pharmacology and experimental therapeutics, 350(1), 153-163 (2014-05-03)

Small molecule phosphodiesterase (PDE) 4 inhibitors have long been known to show therapeutic benefit in various preclinical models of psychiatric and neurologic diseases because of their ability to elevate cAMP in various cell types of the central nervous system. Despite

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