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经验公式(希尔记法):
C13H15NO2S
化学文摘社编号:
分子量:
249.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
VHKZGNPOHPFPER-ONNFQVAWSA-N
SMILES string
CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI
1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble >25 mg/mL, H2O: insoluble
Quality Level
Gene Information
human ... NFKB1(4790)
Application
Bay 11-7085 已被用于:
- Panc-1 细胞、巨噬细胞中的核因子-κB 抑制剂
- 人星形细胞瘤细胞U87MGs中的抑制性κB 激酶IKK抑制剂
- phospho-p65 抑制剂人单核细胞系THP-1
Biochem/physiol Actions
Bay 11-7085可以使过氧化物酶体增殖剂激活受体 γ (PPAR-γ) 失活,并增加微管相关蛋白1A/1B轻链 3B (LC3B),其是一种可导致人滑膜成纤维细胞细胞凋亡的自体吞噬标志物。它会促进胰腺癌的细胞凋亡,并可作为放疗增敏药物。BAY 11-7085通过抑制pI-κBα(核因子κ B 激酶激酶亚单位抑制剂)而减少B细胞淋巴瘤 2 (Bcl-2)。 α
抑制 NF-κB 激活 ICAM-1、VCAM-1、E-选择蛋白、IL-6 和 IL-8 的表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia
Yang G, et al.
The Journal of Clinical Investigation, 114(5), 669-678 (2004)
BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death
Relic B, et al.
Oncotarget, 7(17), 23370-23370 (2016)
Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
Shu C, et al.
International Journal of Clinical and Experimental Medicine, 9(6), 9322-9326 (2016)
Claudia Matteucci et al.
Cell death discovery, 6, 9-9 (2020-03-04)
Adult T cell leukemia/lymphoma (ATL) can be susceptible, at least transiently, to treatments with azidothymidine (AZT) plus IFNα and/or arsenic trioxide. However, the real role of AZT in this effect is still unclear. In fact, while reverse transcriptase (RT) inhibition
Erica Buoso et al.
Archives of toxicology, 94(6), 2081-2095 (2020-04-25)
We previously demonstrated the existence of a balance among steroid hormones, i.e. glucocorticoids and androgens, in RACK1 (receptor for activated C kinase 1) expression and innate immunity activation, which may offer the opportunity to use RACK1 expression as marker to
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