B5681
Bay 11-7085
≥98% (HPLC), solid
别名:
（E）-3-（4-叔丁基苯基）-2-丙烯腈
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关于此项目
经验公式（希尔记法）:
C13H15NO2S
化学文摘社编号:
分子量:
249.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
VHKZGNPOHPFPER-ONNFQVAWSA-N
SMILES string
CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI
1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble >25 mg/mL, H2O: insoluble
Quality Level
Gene Information
human ... NFKB1(4790)
相关类别
Application
Bay 11-7085 已被用于：
- Panc-1 细胞、巨噬细胞中的核因子-κB 抑制剂
- 人星形细胞瘤细胞U87MGs中的抑制性κB 激酶IKK抑制剂
- phospho-p65 抑制剂人单核细胞系THP-1
Biochem/physiol Actions
Bay 11-7085可以使过氧化物酶体增殖剂激活受体 γ (PPAR-γ) 失活，并增加微管相关蛋白1A/1B轻链 3B (LC3B)，其是一种可导致人滑膜成纤维细胞细胞凋亡的自体吞噬标志物。它会促进胰腺癌的细胞凋亡，并可作为放疗增敏药物。BAY 11-7085通过抑制pI-κBα（核因子κ B 激酶激酶亚单位抑制剂）而减少B细胞淋巴瘤 2 (Bcl-2)。 α
抑制 NF-κB 激活 ICAM-1、VCAM-1、E-选择蛋白、IL-6 和 IL-8 的表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia
Yang G, et al.
The Journal of Clinical Investigation, 114(5), 669-678 (2004)
Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
Shu C, et al.
International Journal of Clinical and Experimental Medicine, 9(6), 9322-9326 (2016)
BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death
Relic B, et al.
Oncotarget, 7(17), 23370-23370 (2016)
Qin Yan et al.
PLoS pathogens, 10(6), e1004149-e1004149 (2014-06-06)
Using A/J mice, which are susceptible to Staphylococcus aureus, we sought to identify genetic determinants of susceptibility to S. aureus, and evaluate their function with regard to S. aureus infection. One QTL region on chromosome 11 containing 422 genes was
Jun Yan et al.
Nature communications, 10(1), 448-448 (2019-01-27)
Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout in tumor cells did
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