推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white
溶解性
DMSO: soluble >25 mg/mL
H2O: insoluble
SMILES字符串
CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI
1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
InChI key
VHKZGNPOHPFPER-ONNFQVAWSA-N
基因信息
human ... NFKB1(4790)
应用
Bay 11-7085 已被用于：
- Panc-1 细胞、巨噬细胞中的核因子-κB 抑制剂
- 人星形细胞瘤细胞U87MGs中的抑制性κB 激酶IKK抑制剂
- phospho-p65 抑制剂人单核细胞系THP-1
生化/生理作用
Bay 11-7085可以使过氧化物酶体增殖剂激活受体 γ (PPAR-γ) 失活，并增加微管相关蛋白1A/1B轻链 3B (LC3B)，其是一种可导致人滑膜成纤维细胞细胞凋亡的自体吞噬标志物。它会促进胰腺癌的细胞凋亡，并可作为放疗增敏药物。BAY 11-7085通过抑制pI-κBα（核因子κ B 激酶激酶亚单位抑制剂）而减少B细胞淋巴瘤 2 (Bcl-2)。 α
抑制 NF-κB 激活 ICAM-1、VCAM-1、E-选择蛋白、IL-6 和 IL-8 的表达。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
Shu C, et al.
International Journal of Clinical and Experimental Medicine, 9(6), 9322-9326 (2016)
Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia
Yang G, et al.
The Journal of Clinical Investigation, 114(5), 669-678 (2004)
BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death
Relic B, et al.
Oncotarget, 7(17), 23370-23370 (2016)
Claudia Matteucci et al.
Cell death discovery, 6, 9-9 (2020-03-04)
Adult T cell leukemia/lymphoma (ATL) can be susceptible, at least transiently, to treatments with azidothymidine (AZT) plus IFNα and/or arsenic trioxide. However, the real role of AZT in this effect is still unclear. In fact, while reverse transcriptase (RT) inhibition
Loss of nucleobindin-2 causes insulin resistance in obesity without impacting satiety or adiposity
Ravussin A, et al.
Testing, 24(5), 1085-1092 (2018)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门