B3306
Bisindolylmaleimide IV
≥98% (TLC), solid
别名:
Ro 31-6233
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关于此项目
经验公式（希尔记法）:
C20H13N3O2
化学文摘社编号:
分子量:
327.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
InChI
1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
SMILES string
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45
InChI key
DQYBRTASHMYDJG-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (TLC)
form
solid
color
dark red
solubility
DMSO: soluble, methanol: soluble
storage temp.
−20°C
Quality Level
Gene Information
human ... CDK2(1017), EGFR(1956)
rat ... Prkca(24680)
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Biochem/physiol Actions
Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Hui He et al.
The Prostate, 70(10), 1119-1126 (2010-03-25)
We have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylation. It is known that phorbol ester
B Pajak et al.
Advances in medical sciences, 53(1), 21-31 (2008-07-19)
Bisindolylmaleimide derivatives were originally described as protein kinase C inhibitors. However, several studies have shown that bisindolylmaleimides target several other signaling molecules. The review presents bisindolylmaleimide-mediated PKC-dependent and PKC-independent biological effects, such as reversal of MDR and modulation of Wnt
Neil Grodsky et al.
Biochemistry, 45(47), 13970-13981 (2006-11-23)
The conventional protein kinase C isoform, PKCII, is a signaling kinase activated during the hyperglycemic state and has been associated with the development of microvascular abnormalities associated with diabetes. PKCII, therefore, has been identified as a therapeutic target where inhibitors
Ansar A Khan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(3), 822-829 (2009-12-17)
The vitamin D receptor (VDR) regulates the expression of drug metabolizing enzymes and transporters in intestine and liver, but the regulation of VDR expression in intestine and liver is incompletely understood. We studied the regulation of VDR mRNA expression by
Melike Mut et al.
Turkish neurosurgery, 20(3), 277-285 (2010-07-30)
Protein kinase-C (PKC) and NF-kappaB are involved in cell survival, proliferation, migration and radioresistance in glioblastoma multiforme (GBM). We sought to determine the interaction between PKC and NF-kappaB pathways. The activation of NF-kappaB by PKC alpha and PKC delta was
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