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Merck
CN

B2417

苯扎咪 盐酸盐 水合物

≥98% (HPLC), ENaC and NCX inhibitor, solid

别名:

N-（苄基脒）-3,5-二氨基-6-氯吡嗪甲酰胺 盐酸盐 水合物

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关于此项目

经验公式（希尔记法）:
C13H14ClN7O · HCl · xH2O
化学文摘社编号:
161804-20-2
分子量:
356.21 (anhydrous basis)
MDL编号:
MFCD28147597
UNSPSC代码:
12352200
PubChem化学物质编号:
24278262
NACRES:
NA.77

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产品名称

苯扎咪 盐酸盐 水合物, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

solid

储存条件

desiccated

颜色

yellow

溶解性

methanol: 10 mg/mL
DMSO: >20 mg/mL

储存温度

2-8°C

SMILES字符串

O.Cl.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)NCc2ccccc2

InChI

1S/C13H14ClN7O.ClH.H2O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H;1H2

InChI key

YAJQRPFIYXRNKS-UHFFFAOYSA-N

基因信息

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

相关类别

生化/生理作用

Na + /H + 和 Na + /Ca 2 + 通道的选择性和强效阻断剂

特点和优势

该化合物是受体分类及信号转导手册上酸感应（质子门控）离子通道 (ASIC)页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

其他说明

阿米洛利的 Nω-苄基衍生物。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000351697
0000351697
0000180747
0000180747
0000129799

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J W Lane et al.
British journal of pharmacology, 106(2), 283-286 (1992-06-11)
1. Patch clamp recording techniques have been used to compare the block caused by amiloride and some of its structural analogues of the mechanosensitive (MS) cation selective channel in frog (Xenopus laevis) oocytes. 2. Like amiloride, the amiloride analogues dimethylamiloride
A Catalina Vélez-Ortega et al.
eLife, 6 (2017-03-30)
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca2+
G N Pierce et al.
The Journal of pharmacology and experimental therapeutics, 265(3), 1280-1291 (1993-06-01)
Amiloride and its derivatives (benzamil, dichlorobenzamil, 5-(N,N-dimethyl)-amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, (N,N-hexamethylene)- amiloride and 5-(N-methyl-N-isobutyl)-amiloride) are commonly used as selective blockers of Na+/Ca++ exchange or Na+/H+ exchange. Very little information is currently available regarding their effects on cardiac performance. It was observed that
Ningyong Xu et al.
PloS one, 16(4), e0250095-e0250095 (2021-04-24)
Collective migration of endothelial cells is important for wound healing and angiogenesis. During such migration, each constituent endothelial cell coordinates its magnitude and direction of migration with its neighbors while retaining intercellular adhesion. Ensuring coordination and cohesion involves a variety
Xu Yang et al.
Oxidative medicine and cellular longevity, 2020, 3921897-3921897 (2020-11-17)
Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis
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