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Merck
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安全信息

B150

Sigma-Aldrich

BQ-123

≥99%, sodium salt, lyophilized powder

别名:

BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

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About This Item

经验公式（希尔记法）:
C31H41N6O7 Na
CAS号:
136553-81-6
分子量:
632.68
MDL编号:
MFCD00133204
UNSPSC代码:
12352204
PubChem化学物质编号:
24891595
NACRES:
NA.32

质量水平

200

检测方案

≥99%

形式

lyophilized powder

储存温度

−20°C

SMILES字符串

[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C

InChI

1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

InChI key

VYCMAAOURFJIHD-PJNXIOHISA-N

基因信息

human ... EDNRA(1909) , EDNRB(1910)
rat ... Ednra(24326) , Ednrb(50672)

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相关类别

Amino Acid Sequence

cyclo-Asp-Pro-Val-Leu-Trp

应用

BQ-123已用作选择性内皮素-A受体拮抗剂，研究其对肿瘤坏死因子α(TNFα)诱导的人气道平滑肌细胞(HASMC)增殖的影响。作为内皮素-A受体拮抗剂，它还用于研究其对TNFα诱导的粒细胞-巨噬细胞集落刺激因子(GM-CSF) 表达的影响。

生化/生理作用

BQ-123是一种内皮素(Et)受体拮抗剂，对内皮素A(ETA)受体敏感。它是一种环五肽。
选择性ETA内皮素受体拮抗剂。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How should Product B150, BQ-123, be dissolved?

    This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.

  4. Is Product B150 the free acid form of BQ-123, or is it a salt?

    Product No. B150 is BQ123 sodium salt.

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. What is the solution stability for Product B150, BQ-123?

    We do not perform any solution stability studies on Product B150, BQ-123. The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned.  Cardillo, C. et al., Hypertension, 33, 753-758 (1999).  The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment.  Bonvollet, S. et al., A.J.P. - Heart, 266 (4), H1327-H1331 (1994).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

J Knobloch et al.
Thorax, 64(12), 1044-1052 (2009-10-24)
There is an urgent need to inhibit endothelin-1 (ET-1) induced chronic inflammatory processes in early stages of lung diseases in order to prevent untreatable irreversible stages often accompanied by lung fibrosis and pulmonary hypertension. Nothing is known about the airway
M Clozel et al.
Life sciences, 52(9), 825-834 (1993-01-01)
The aim of this study was to evaluate the role of endothelin and endothelin ETA receptor in the early cerebral vasoconstriction following subarachnoid hemorrhage (SAH) in the rat. SAH induced by injection of autologous blood in the cisterna magna reduced
F Cosentino et al.
Journal of cardiovascular pharmacology, 22 Suppl 8, S332-S335 (1993-01-01)
The present study was designed to determine whether an endothelinA (ETA)-receptor antagonist BQ-123 (cyclo[Dtrp, Dasp, pro-D-Val-Leu]) or an ET-converting enzyme inhibitor phosphoramidon may prevent development of cerebral vasospasm after subarachnoid hemorrhage (SAH). A "double hemorrhage" canine model of the disease
T D Warner et al.
British journal of pharmacology, 112(1), 207-213 (1994-05-01)
1. Endothelin-1 binds almost irreversibly to its receptors and causes prolonged vasoconstrictions. Here we have studied the reversal of established responses to ET-1 in vivo and in vitro by BQ-123, an ETA receptor-selective antagonist, and/or PD 145065, an ETA/ETB receptor
K Wolff et al.
Acta obstetricia et gynecologica Scandinavica, 75(5), 432-438 (1996-05-01)
To compare the effect of endothelin on isolated resistance arteries from different vascular beds in normal and preeclamptic women before and after pretreatment with the ETA receptor antagonist BQ-123. Resistance arteries from myometrial and omental biopsies obtained at cesarean section
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