B0936
BRL 50481
≥98% (HPLC), solid
别名:
5-Nitro-2,N,N-trimethylbenzenesulfonamide
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关于此项目
经验公式（希尔记法）:
C9H12N2O4S
化学文摘社编号:
分子量:
244.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
BRL 50481, ≥98% (HPLC), solid
InChI
1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
SMILES string
CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
InChI key
IFIUFCJFLGCQPH-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >10 mg/mL
H2O: insoluble
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Gene Information
human ... PDE7A(5150), PDE7B(27115)
Biochem/physiol Actions
BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Lucie Jiraskova et al.
Molecular pharmaceutics, 15(7), 2732-2741 (2018-05-22)
Equilibrative ( SLC29A) and concentrative ( SLC28A) nucleoside transporters contribute to proper placental development and mediate uptake of nucleosides/nucleoside-derived drugs. We analyzed placental expression of SLC28A mRNA during gestation. Moreover, we studied in choriocarcinoma-derived BeWo cells whether SLC29A and SLC28A
Maike Monzel et al.
FEBS letters, 588(18), 3469-3474 (2014-08-17)
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3',5'-cyclic monophosphate (cNMP) specificity of six different recombinant phosphodiesterases (PDEs) by using a highly-sensitive HPLC-MS/MS detection method. PDE7A1 was the only enzyme that
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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