质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white to off-white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
创始人
GlaxoSmithKline
储存温度
2-8°C
SMILES字符串
CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
InChI
1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
InChI key
IFIUFCJFLGCQPH-UHFFFAOYSA-N
基因信息
human ... PDE7A(5150) , PDE7B(27115)
生化/生理作用
BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
Sold for research purposes under agreement from GlaxoSmithKline
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Molecular pharmaceutics, 15(7), 2732-2741 (2018-05-22)
Equilibrative ( SLC29A) and concentrative ( SLC28A) nucleoside transporters contribute to proper placental development and mediate uptake of nucleosides/nucleoside-derived drugs. We analyzed placental expression of SLC28A mRNA during gestation. Moreover, we studied in choriocarcinoma-derived BeWo cells whether SLC29A and SLC28A
FEBS letters, 588(18), 3469-3474 (2014-08-17)
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3',5'-cyclic monophosphate (cNMP) specificity of six different recombinant phosphodiesterases (PDEs) by using a highly-sensitive HPLC-MS/MS detection method. PDE7A1 was the only enzyme that
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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