Anti-NR3C2 antibody produced in rabbit

Mineralocorticoid receptor/nuclear receptor subfamily 3, group C, member 2/ (NR3C2, MLR, MCR) is a nuclear receptor for mineralocorticoids (eg. aldosterone) and glucocorticoids (eg. cortisol) that activates expression of proteins involved with ionic (salt balance) and water transport such as the epithelial sodium channel, Na+/K+ pump and serum and glucocorticoid induced kinase (SGK1).

Anti-NR3C2 polyclonal antibody reacts with chicken, human, mouse, and rat mineralocorticoid/ aldosterone receptors.

Synthetic peptide directed towards the middle region of human NR3C2

Anti-NR3C2 polyclonal antibody is used to tag mineralocorticoid receptor protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of mineralocorticoid receptor in the mineralocorticoid and glucocorticoid ligand-dependent control of salt balance and water retention.

NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Synthetic peptide located within the following region: RRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPP

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

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