产品名称
抗-MMP9 兔抗, IgG fraction of antiserum
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
78 kDa
species reactivity
human, dog, mouse, guinea pig, horse, bovine, sheep, rat, rabbit
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MMP9(4318)
Application
兔抗-MMP9多克隆抗体用于标记基质金属蛋白酶-9 /明胶酶B，以通过免疫细胞化学和免疫组化(IHC)技术进行检测和定量。这种多克隆抗体可用作探针，以确定工艺过程是否存在基质金属蛋白酶 9 /明胶酶 B 以及这类酶所承担的作用，如突触可塑性。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
Biochem/physiol Actions
在正常的生理过程（如胚胎发育、繁殖和组织重建）以及疾病过程（如关节炎和代谢）中，基质金属蛋白酶 (MMP) 家族蛋白质参与细胞外基质的分解。大多数 MMP 分泌为无活性的前蛋白，在被细胞外蛋白酶切割时会激活。 MMP9 编码的酶可降解 IV 型和 V 型胶原。在恒河猴中的研究表明，该酶参与了 IL-8 诱导的骨髓造血祖细胞动员，而鼠类研究表明，其在肿瘤相关的组织重建中发挥作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
General description
基质金属蛋白酶9 /明胶酶B (MMP-9)是基质金属蛋白酶 (MMP) 家族成员，参与细胞外基质的分解，从而在正常生理过程（如胚胎发育、组织重建、伤口愈合\血管生成和炎症反应）中发挥作用。 MMP-9参与突触可塑性。 MMP-9可参与调节海马突触生理学和可塑性。
Immunogen
靶向人 MMP9 N 末端区域的合成肽
Other Notes
合成肽位于以下区域内：VAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTR
Physical form
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Perle Latré De Laté et al.
Cellular microbiology, 21(3), e12973-e12973 (2018-11-10)
Constitutive c-Jun N-terminal kinase (JNK) activity characterizes bovine T and B cells infected with Theileria parva, and B cells and macrophages infected with Theileria annulata. Here, we show that T. annulata infection of macrophages manipulates JNK activation by recruiting JNK2 and
Prashant Nighot et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(12), G988-G997 (2015-10-31)
Recent studies have implicated a pathogenic role for matrix metalloproteinases 9 (MMP-9) in inflammatory bowel disease. Although loss of epithelial barrier function has been shown to be a key pathogenic factor for the development of intestinal inflammation, the role of
Gokhan Gundogdu et al.
International journal of impotence research, 36(3), 269-274 (2023-02-14)
Peyronie's disease (PD) is a debilitating pathology which is associated with penile curvature and erectile dysfunction due to the formation of fibrotic plaques in the penile tunica albuginea. In the present study, we developed a novel rabbit model of PD
K Nagaoka et al.
Oncogene, 35(22), 2893-2901 (2015-09-29)
In mouse mammary epithelial cells, cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediates the apical localization of ZO-1 mRNA, which encodes a critical tight junction component. In mice lacking CPEB1 and in cultured cells from which CPEB has been depleted
Qiang Zhang et al.
Chinese medical journal, 135(9), 1076-1086 (2022-02-23)
Fibrosis in the peripheral airways contributes to airflow limitation in patients with chronic obstructive pulmonary disease (COPD). However, the key proteins involved in its development are still poorly understood. Thus, we aimed to identify the differentially expressed proteins (DEPs) between
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