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Merck
CN
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文件

安全信息

A9968

Sigma-Aldrich

N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide

≥95%

别名:

Ac-IETD-pNA

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About This Item

经验公式（希尔记法）:
C27H38N6O12
分子量:
638.62
MDL编号:
MFCD01318840
UNSPSC代码:
12352209
PubChem化学物质编号:
329771065
NACRES:
NA.32

质量水平

200

检测方案

≥95%

形式

powder

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1

InChI key

FHURKTIGZAIQGR-BQCLNCLCSA-N

基因信息

human ... CARD8(22900) , CASP8(841) , CASP8AP2(9994) , CFLAR(8837) , GZMB(3002)
mouse ... CFLAR(117279) , GZMB(171528)
rat ... CASP8(12370) , CFLAR(12633) , GZMB(14939) , RGD1561819(502004) , RGD1562700(502007)

Amino Acid Sequence

NAc-Ile-Glu-Thr-Asp-pNA

应用

Chromogenic substrate for caspase 8 and granzyme B.

生化/生理作用

IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

相关产品

产品编号
说明
价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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