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Merck
CN

A9810

Sigma-Aldrich

淀粉样蛋白β蛋白片段1-42

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经验公式(希尔记法):
C203H311N55O60S
分子量:
4514.04
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.32

检测方案

≥95% (HPLC)

质量水平

形式

powder

UniProt登记号

储存温度

−20°C

基因信息

human ... APP(351)

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

一般描述

淀粉样蛋白β蛋白由淀粉样蛋白-β 前体蛋白(APP)产生。它由两个C末端变体组成,例如长尾的Aβ 1-42及短尾的Aβ 1-40。APP位于人染色体21q21.3。

应用

淀粉样蛋白β蛋白片段1-42已用于:
  • Aβ 1-42低聚体的制备
  • western blot分析
  • 免疫磁性降低(IMR)血浆Aβ42检测的干扰试验
  • 研究白藜芦醇对Aβ 1-42诱导的空间学习、记忆和突触可塑性损害的影响
  • 研究Aβ在上皮细胞培养中的作用

生化/生理作用

在阿尔茨海默症和唐氏综合症患者的大脑中发现了淀粉样蛋白β-蛋白的主要片段。
淀粉样蛋白β蛋白片段1-42 (Aβ 1-42) 具有抗氧化及神经保护性质。淀粉样蛋白β蛋白的积累与阿尔兹海默症(AD)和唐氏综合症相关。Aβ 1-42可调节胆固醇的转运并可作为一种转录因子。它可能还具有抗炎及抗微生物的作用。

相关产品

产品编号
说明
价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is the mouse protein fragment the same as the human protein fragment in Product A9810, Amyloid β Protein Fragment 1-42?

    The homology is 93% by identity, 95% positives...  no gaps

  6. What is the source of Product A9810, Amyloid β Protein Fragment 1-42?

    This protein fragment is a synthetic organic.  The gene for this peptide is located on human chromosome 21.

  7. What is the secondary structure of Product A9810, Amyloid β Protein Fragment 1-42?

    The secondary structure of this fragment will exist as a mixture of B-sheet, a-helix, and random coil structures dependent upon the solution conditions as described in J. Mol. Biol., 225, 1075-1083, 1992

  8. What is the pI of Product A9810, Amyloid β Protein Fragment 1-42?

    The pI as calculated from the amino acid sequence for Product A9810, Amyloid β Protein Fragment 1-42, is 5.31.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity
Yao ZX and Papadopoulos V
Faseb Journal, 16(12), 1677-1679 (2002)
Kyunghee Byun et al.
PloS one, 7(5), e37917-e37917 (2012-06-05)
Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we demonstrate that AGE-albumin, the most abundant AGE product in human
Resveratrol ameliorates spatial learning memory impairment induced by Abeta1-42 in rats
Wang R, et al.
Neuroscience, 344, 39-47 (2017)
The role of Abeta circRNA in Alzheimer? s disease: alternative mechanism of Abeta biogenesis from Abeta circRNA translation
Mo D, et al.
bioRxiv, 260968-260968 (2018)
Plasma Amyloid-beta(Abeta 42) Correlates with Cerebrospinal Fluid Abeta 42 in Alzheimer?s Disease
Teunissen CE, et al.
Journal of Alzheimer'S Disease, 1-7 (2018)

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