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质量水平
检测方案
≥98.5% (HPLC)
形式
powder
颜色
white
mp
260 °C (dec.) (lit.)
溶解性
H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChI key
IVOMOUWHDPKRLL-KQYNXXCUSA-N
基因信息
human ... OPRK1(4986)
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相关类别
应用
腺苷3′,5′-环一磷酸已用于：
- 在胚胎脊髓神经细胞培养中作为细胞培养基补充剂
- 作为灌注研究中林格溶液的一个组成部分
- 在人肺癌细胞系中诱导神经内分泌分化
生化/生理作用
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使，并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示，cAMP/PKA 信号通路可抑制细胞增殖，诱导分化并导致细胞凋亡。
特点和优势
该化合物是用于ADME Tox和环核苷酸研究的特色产品。发现更多精选用于 ADME Tox 和 环核苷酸 研究的产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Nature Protocols, 13(3), 565-565 (2018)
Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer
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Biochimica et Biophysica Acta - Molecular Cell Research, 1865(12), 1878-1890 (2018)
Linghai Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4896-4904 (2014-04-04)
Striatal medium spiny neurons (MSNs) mediate many of the physiological effects of dopamine, including the regulation of feeding and motor behaviors. Dopaminergic inputs from the midbrain modulate MSN excitability through pathways that involve cAMP and protein kinase A (PKA), but
Cory M Johannessen et al.
Nature, 504(7478), 138-142 (2013-11-05)
Malignant melanomas harbouring point mutations (Val600Glu) in the serine/threonine-protein kinase BRAF (BRAF(V600E)) depend on RAF-MEK-ERK signalling for tumour cell growth. RAF and MEK inhibitors show remarkable clinical efficacy in BRAF(V600E) melanoma; however, resistance to these agents remains a formidable challenge.
Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons
Guo X, et al.
Biomaterials, 33(23), 5723-5731 (2012)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
相关内容
Discover Bioactive Small Molecules for ADME/Tox
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