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安全信息

A9477

Sigma-Aldrich

醛固酮

≥95% (HPLC), powder

别名:

11β，21-二羟基-3，20-二氧代-4-孕-18-烯醛, 11β，21-二羟孕-4-烯-3，18，20-三酮, 18-醛固酮, Reichstein X

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About This Item

经验公式（希尔记法）:
C21H28O5
CAS号:
52-39-1
分子量:
360.44
Beilstein:
3224996
EC 号:
200-139-9
MDL编号:
MFCD00051136
UNSPSC代码:
51111800
PubChem化学物质编号:
24891458
NACRES:
NA.77

product name

醛固酮, ≥95% (HPLC)

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

检测方案

≥95% (HPLC)

形式

powder

技术

cell culture | mammalian: suitable

溶解性

chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow

运输

ambient

储存温度

room temp

SMILES字符串

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

基因信息

human ... SERPINA6(866)
rat ... Ar(24208) , Nr3c2(25672)

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一般描述

Aldosterone plays a significant role in the multi-factorial regulation of salt, potassium, blood pressure, and acid-base balance. It is also involved in maternal volume expansion during fetal development to support fetal perfusion and may contribute to the increased expression of placental growth factors. While its primary activity is associated with the kidney, aldosterone can also interact with mineralocorticoid receptors in other tissues such as the gastrointestinal tract, respiratory epithelium, myocardium, and vascular smooth muscle. Aldosterone antagonists or mineralocorticoid receptor antagonists (MRAs) can be beneficial for patients with various clinical conditions, including primary aldosteronism (PA), primary and resistant hypertension, heart failure (HF), and chronic kidney disease (CKD).

应用

醛固酮已被用于：
  • 作为足细胞培养的RPMI-1640培养基补充，以测试其在肥胖相关肾小球病(ORG)中的致病性
  • 结合盐诱导小鼠肾损伤
  • 刺激原发性肝窦内皮细胞(LSEC)和小鼠醛固酮增多症模型的产生

醛固酮的D-异构体被认为是具有生物活性的异构体。

生化/生理作用

醛固酮是一种具有生物活性的醛固酮异构体；肾上腺激素由肾上腺皮质产生的一种矿物质皮质激素。它可以诱导尿中K+排出，肾中Na+再吸收。它由促肾上腺皮质激素(ACTH)产生，对维持远端小管的钠稳态至关重要。醛固酮结合到矿糖皮质激素受体，可调节血管系统和诱导肾损害。它有助于慢性肾脏疾病(CKD)的进展。醛固酮是肾素-血管紧张素-醛固酮系统(RAAS)的一部分。

其他说明

以醛和半缩醛的平衡混合物形式存在。

相关产品

产品编号
说明
价格

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Product A9477, Aldosterone, the d- or l- isomer?

    The A9477 is the d-Aldosterone (per our supplier), which is considered to be the biologically active isomer.

  6. How do I make a stock solution of Product A9477, Aldosterone?

    To prepare a 100 μg/ml stock solution, add 5 ml of absolute ethanol to 5 mg, gently swirl to dissolve, then add 45 ml sterile medium. Freeze the stock in working aliquots, but avoid repeated freeze/thaw cycles.

  7. Is Product A9477, Aldosterone, tested for solubility?

    Yes, A9477 is tested for solubility using 20mg/ml in chloroform. For biological applications, you can solubilize aldosterone in ethanol to at least 1 mg/mL. Please refer to literature references for further solubility information.

  8. What is the difference between Aldosterone Products A9477 and 05521?

    The main differences between A9477 and 05521 are the assays performed on the products. The assay results are lot specific and can be viewed on the Certificate of Analysis.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Aldosterone and renin measurements
Cartledge S and Lawson N
Annals of Clinical Biochemistry, 37(3), 262-278 (2000)
Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone-and salt-induced renal injury
Hisamichi M
Hypertension Research, 41(1), 8-8 (2018)
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Luo X, et al.
Redox Biology, 13(5), 508-521 (2017)
Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology
Cannavo A, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Seong-Mi Park et al.
Journal of clinical medicine, 8(7) (2019-07-20)
Although aldosterone has been demonstrated to induce left ventricular (LV) hypertrophy not only in primary aldosteronism but also in primary hypertension (HT), it can be affected by multiple factors, including age, and the effect of aldosterone on LV function is
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