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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white to light tan
溶解性
DMSO: ≥20 mg/mL
储存温度
room temp
SMILES字符串
OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
InChI key
MNIPYSSQXLZQLJ-UHFFFAOYSA-N
基因信息
human ... PTGS2(5743)
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应用
Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay. It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.
生化/生理作用
Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
An insight into the binding of aceclofenac with bovine serum albumin at physiological condition: a spectroscopic and computational approach.
Neeraj Dohare et al.
Journal of biomolecular structure & dynamics, 36(2), 398-406 (2017-01-25)
K Karthikeyan et al.
AAPS PharmSciTech, 13(1), 143-149 (2011-12-15)
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability
R Andrew Moore et al.
The Cochrane database of systematic reviews, (3)(3), CD007588-CD007588 (2009-07-10)
Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy
S S Kulthe et al.
Colloids and surfaces. B, Biointerfaces, 88(2), 691-696 (2011-08-25)
Pluronic block copolymers offer affluent phase behavioral characteristics and are extensively investigated for drug delivery applications. Hydrophobic Pluronics produce larger aggregates whereas hydrophilic Pluronics often generate small-sized micelles in aqueous milieu. To overcome the limitations and combine the advantages of
Kyung Rok Chu et al.
Archives of pharmacal research, 35(7), 1187-1195 (2012-08-07)
This study examined the effects of the particle size of various poorly water-soluble drugs on their dissolution behavior through physicochemical and mathematical analysis. As model drugs, hydrochlorothiazide, aceclofenac, ibuprofen and a discovery candidate were selected. The materials were crystallized using
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