所有图片(1)
About This Item
经验公式（希尔记法）:
C22H25NO3
CAS号:
分子量:
351.44
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
solid
储存温度
−20°C
SMILES字符串
CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O
InChI
1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChI key
SZWKGOZKRMMLAJ-UHFFFAOYSA-N
基因信息
human ... RARA(5914) , RARB(5915)
一般描述
AM580是视黄苯甲酸衍生物和RAR-α（视黄酸受体-α）激动剂。它刺激 NB4 早幼粒细胞白血病细胞系和 APL（急性早幼粒细胞白血病）原始细胞中粒细胞的成熟。AM580 抑制子宫内膜癌细胞增殖。
应用
类视黄醇衍生物用于白血病-视黄酸受体 (PHL-RAR) 细胞系分化的基因表达研究。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Gastroenterology, 159(1), 214-226 (2020-04-05)
Intestinal microfold (M) cells are a unique subset of intestinal epithelial cells in the Peyer's patches that regulate mucosal immunity, serving as portals for sampling and uptake of luminal antigens. The inability to efficiently develop human M cells in cell
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Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes. We have generated transgenic mice lacking Cyp26b1 and have observed increased RA levels in embryonic testes. Cyp26b1(-/-) germ cells
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