A7736
白蛋白 人
recombinant, expressed in Pichia pastoris, lyophilized powder, ≥90% (agarose gel electrophoresis)
别名:
Albagen™, rHSA
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关于此项目
经验公式（希尔记法）:
C2936H4624N786O889S41
化学文摘社编号:
分子量:
66471.53
UNSPSC Code:
12352202
NACRES:
NA.25
EC Number:
274-272-6
MDL number:
eCl@ss:
42010201
Biological source:
human
Assay:
≥90% (agarose gel electrophoresis)
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
biological source
human
Quality Level
recombinant
expressed in Pichia pastoris
assay
≥90% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer ~67 kDa
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
General description
从N端删除单个Asp可产生低过敏性构建体。X射线晶体学证实了其与天然白蛋白的结构等同性。Asp缺失通过消除白蛋白主要的铜镍结合位点而去除了重要的抗原决定簇。人白蛋白的前三个残基被认为是非结构性的。还在Cys34上进行阻断，以改善稳定性、单体含量和均一性。
Application
该重组变异建议用于：吸收、分散、代谢和排泄（ADME）药理学研究；细胞培养；药物递送研究；细胞冻存。
Biochem/physiol Actions
白蛋白是可见于动物体液和组织及部分植物种子的一类可溶性单体蛋白。 血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白。 血清白蛋白在调节血液的胶体渗透压方面也至关重要。
Other Notes
更多信息参见人血清白蛋白。
Legal Information
Albagen is a trademark of Albumin Therapeutics, LLC.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Mika Suga et al.
Methods in molecular biology (Clifton, N.J.), 1965, 35-48 (2019-05-10)
Cranial neural crest cells (NCCs) migrate to the branchial arches and give rise to the majority of cranial mesenchyme that eventually differentiates into odontoblasts, cartilage, craniofacial bone, and connective tissue; a subset of these cells differentiate into cranial ganglia. Here
Insights into the effects of N-glycosylation on the characteristics of the VC1 domain of the human receptor for advanced glycation end products (RAGE) secreted by Pichia pastoris.
Degani, et al.
Glycoconjugate Journal, 36, 27-38 (2020)
Francesco Scavello et al.
Aging, 11(6), 1648-1663 (2019-03-25)
The receptor for advanced glycation end-products (RAGE) recognizes several ligands involved in inflammatory diseases. Two circulating soluble isoforms exist: esRAGE derived from alternative splicing and cRAGE generated by the membrane-bound RAGE (FL-RAGE) proteolysis. Together, esRAGE and cRAGE constitute sRAGE and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A7736-1G | 04061833386248 |