一般描述
Albumin (ALB) is an autosomal gene with 15 exons mapped to human chromosome 4q13.3. The gene codes for a circulating human albumin protein containing 585 amino acid residues and 17 disulfide bridges. It is biosynthesized in the hepatocyte.
免疫原
purified human albumin
应用
Anti-Albumin antibody produced in goat has been used in sandwich enzyme linked immunosorbent assays (ELISA), quantitative precipitin assay and immunofluorescence.
生化/生理作用
Albumin is a transport protein that binds a broad range of ligands such as fatty acids, bilirubin, hemin, drugs, amino acids and ions among several others. Albumin may also function as a zinc carrier protein and consequently regulate physiological processes.
外形
Supplied as a liquid containing 15mM sodium azide as preservative.
制备说明
treated to remove lipoproteins
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A novel mutation in the albumin gene (c.1A>C) resulting in analbuminemia
Caridi G, et al.
European Journal of Clinical Investigation, 43, 72-78 (2013)
Maja Thim Larsen et al.
Journal of controlled release : official journal of the Controlled Release Society, 287, 132-141 (2018-07-18)
Recombinant albumin-drug genetic fusions are an effective technology to prolong the serum half-life of therapeutics that has resulted in marketed products. Indirect evidence suggests albumin fusions' long circulation is controlled by engagement with the cellular recycling neonatal Fc receptor (FcRn)
Albumin as fatty acid transporter
van der Vusse GJ
Drug Metabolism and Pharmacokinetics, 24, 300-307 (2009)
C Magnon et al.
Gene therapy, 15(21), 1436-1445 (2008-06-13)
Given as a prophylactic treatment, a single muscle electrogene transfer of plasmid coding canstatin fused to human serum albumin (CanHSA), slowed down the development of two xenografted human carcinomas from mammary (MDA-MB-231) and prostate origin (PC-3) in nude mice and
N Shaklai et al.
The Journal of biological chemistry, 259(6), 3812-3817 (1984-03-25)
Approximately 10% of the albumin in normal human serum is modified by nonenzymatic glycosylation, primarily at the epsilon-amino group of lysine residue 525. Incubation of albumin with glucose under physiological conditions in vitro resulted in glycosylation of the same residue.
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