A7000
碘化乙酰胆碱
≥97%
别名:
ACh
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关于此项目
线性分子式:
(CH3)3N(I)CH2CH2OCOCH3
化学文摘社编号:
分子量:
273.11
UNSPSC Code:
12352107
NACRES:
NA.25
PubChem Substance ID:
EC Number:
218-862-3
Beilstein/REAXYS Number:
3571339
MDL number:
产品名称
碘化乙酰胆碱, ≥97%
InChI key
SMBBQHHYSLHDHF-UHFFFAOYSA-M
InChI
1S/C7H16NO2.HI/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
SMILES string
[I-].CC(=O)OCC[N+](C)(C)C
assay
≥97%
form
powder
storage temp.
−20°C
Quality Level
Gene Information
human ... CHRM3(1131)
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Application
乙酰胆碱是胆碱能突触的内源性神经递质，可放大肌膜的操作电位，从而诱导肌肉收缩。碘化乙酰胆碱用作鉴别、表征和区分胆碱能受体类型的乙酰胆碱受体激动剂。碘化乙酰胆碱用作鉴别和表征天然和突变乙酰胆碱酯酶的底物。
Biochem/physiol Actions
胆碱能突触中的内源性神经递质，通过增强肌膜动作电位来触发肌肉收缩反应。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(12), 5319-5325 (2013-03-22)
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Xun Qian et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(1), 127-135 (2013-11-02)
Intermediate and small conductance KCa channels IK1 (KCa3.1) and SK3 (KCa2.3) are primary targets of endothelial Ca(2+) signals in the arterial vasculature, and their ablation results in increased arterial tone and hypertension. Activation of IK1 channels by local Ca(2+) transients
Tracey Huynh et al.
Journal of medicinal chemistry, 56(20), 8196-8200 (2013-10-01)
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library
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