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A6402

[Asn¹, Val⁵]-血管紧张素 II

Name: [Asn<SUP>1</SUP>, Val<SUP>5</SUP>]-血管紧张素 II
Brand: SIGMA

≥97% (HPLC), angiotensin agonist, powder

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关于此项目

经验公式（希尔记法）:

C₄₉H₇₀N₁₄O₁₁

化学文摘社编号:

20071-00-5

分子量:

1031.17

UNSPSC Code:

12352209

PubChem Substance ID:

329770893

NACRES:

NA.32

MDL number:

MFCD00167643

Assay:

≥97% (HPLC)

Form:

powder

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属性

产品名称

[Asn¹, Val⁵]-血管紧张素 II, ≥97% (HPLC)

Quality Segment

200

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)/t32-,33-,34-,35-,36-,37-,39-,40-/m0/s1

InChI key

JYPVVOOBQVVUQV-CGHBYZBKSA-N

Gene Information

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

说明

General description

Angiotensin II is a renin-angiotensin system (RAS) effector molecule, which binds to angiotensin II type-1 (AT₁R) and angiotensin II type-2 (AT₂R) receptors. The gene is located on human chromosome 3q24. Angiotensin II is mainly expressed in vessel walls, lung and kidney.

Application

[Asn¹, Val⁵]-Angiotensin II has been used:

to study the effects of ACTH, serotonin, Ang II, carbachol and elevated [K⁺] on catecholamine and serotonin release
to induce cyclophilin D (CypD)–dependent mitochondrial vascular superoxide (O2^{. -} ) production in hypertension
to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells

Biochem/physiol Actions

Angiotensin II functions as a vasoconstrictor and controls cardiovascular function. It maintains water-sodium homeostasis, modulates cellular proliferation and vascular remodelling of renin-angiotensin system. Angiotensin II has inflammatory effects.

与鱼类体内的血压、耗水量以及矿物质平衡的调节有关的合成紧张素激动剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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