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生物来源
synthetic (organic)
质量水平
方案
≥97% (TLC)
表单
powder
颜色
white
溶解性
DMSO: soluble
ethanol: soluble
储存温度
−20°C
SMILES字符串
[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI
1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
基因信息
human ... CAPN1(823) , CTSB(1508) , PSMA1(5682)
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应用
钙蛋白酶抑制剂I已被用于:
- 作为蛋白酶抑制剂混合物的成分,用于凝胶位移分析
- 处理HeLa细胞培养物
- 在26 S蛋白酶体抑制测定中抑制26 S蛋白酶体
生化/生理作用
可引发HL-60细胞的细胞凋亡,但可阻断地塞米松诱导的胸腺细胞凋亡和环己酰亚胺诱导的间质细胞凋亡。 抑制细胞周期蛋白B降解,将细胞周期停滞在G1/S和中/后期。 阻断LPS在巨噬细胞中诱导一氧化氮合酶。
钙蛋白酶抑制剂I可抑制肿瘤坏死因子诱导的(TNF诱导的)聚(ADP-核糖)聚合酶(PARP)和钙蛋白酶抑制素的裂解。它还可抑制氧/葡萄糖剥夺(OGD)诱导的caspase-12和Bcl-xL的裂解。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression
Journal of Immunology, 165(3), 1612-1617 (2000)
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles
Journal of Cell Science, 115(16), 3275-3284 (2002)
CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein
The Journal of Biological Chemistry, 283(17), 11661-11676 (2008)
Journal of cellular physiology, 159(2), 229-237 (1994-05-01)
Programmed cell death is an active process wherein the cell initiates a sequence of events culminating in the fragmentation of its DNA, nuclear collapse, and disintegration of the cell into small, membrane-bound apoptotic bodies. Examination of the death program in
Archives of biochemistry and biophysics, 334(1), 175-181 (1996-10-01)
Recent investigations indicate that proteolysis is an important event in generation of the apoptosis phenotype. Although various proteases have been suggested to be candidates for this proteolysis, the results from different laboratories are inconsistent. In the present studies, HL-60 cells
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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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