生物来源
synthetic (organic)
质量水平
检测方案
≥97% (TLC)
形式
powder
颜色
white
溶解性
DMSO: soluble
ethanol: soluble
储存温度
−20°C
SMILES字符串
[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI
1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
基因信息
human ... CAPN1(823) , CTSB(1508) , PSMA1(5682)
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应用
钙蛋白酶抑制剂I已被用于：
- 作为蛋白酶抑制剂混合物的成分，用于凝胶位移分析
- 处理HeLa细胞培养物
- 在26 S蛋白酶体抑制测定中抑制26 S蛋白酶体
生化/生理作用
可引发HL-60细胞的细胞凋亡，但可阻断地塞米松诱导的胸腺细胞凋亡和环己酰亚胺诱导的间质细胞凋亡。 抑制细胞周期蛋白B降解，将细胞周期停滞在G1/S和中/后期。 阻断LPS在巨噬细胞中诱导一氧化氮合酶。
钙蛋白酶抑制剂I可抑制肿瘤坏死因子诱导的（TNF诱导的）聚（ADP-核糖）聚合酶（PARP）和钙蛋白酶抑制素的裂解。它还可抑制氧/葡萄糖剥夺（OGD）诱导的caspase-12和Bcl-xL的裂解。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Cleavage of the calpain inhibitor, calpastatin, during apoptosis
Porn-Ares M I, et al.
Cell Death and Differentiation, 5(12), 1028-1028 (1998)
J M Griscavage et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(8), 3308-3312 (1996-04-16)
The objective of this study was to elucidate the role of the proteasome pathway or multicatalytic proteinase complex in the induction of immunologic nitric oxide (NO) synthase (iNOS) in rat alveolar macrophages activated by lipopolysaccharide. Macrophages were incubated in the
S W Sherwood et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3353-3357 (1993-04-15)
The cytotoxic neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal (ALLN) inhibits cell-cycle progression in CHO cells, affecting the G1/S and metaphase-anaphase transition points, as well as S phase. Mitotic arrest induced by ALLN is associated with the inhibition of cyclin B degradation.
CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein
Cheong J K, et al.
The Journal of Biological Chemistry, 283(17), 11661-11676 (2008)
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles
Mayor T, et al.
Journal of Cell Science, 115(16), 3275-3284 (2002)
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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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