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Merck
CN
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文件

A5835

Sigma-Aldrich

γ-氨基丁酸

≥99%, suitable for ligand binding assays, BioXtra

别名:

3-羧丙胺, 4-氨基丁酸, GABA, 哌啶酸, 氨酪酸

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About This Item

线性分子式:
NH2(CH2)3COOH
CAS号:
56-12-2
分子量:
103.12
Beilstein:
906818
EC 号:
200-258-6
MDL编号:
MFCD00008226
UNSPSC代码:
12352106
PubChem化学物质编号:
24891025
NACRES:
NA.26

product name

γ-氨基丁酸, BioXtra, ≥99%

产品线

BioXtra

质量水平

200

检测方案

≥99%

形式

powder

技术

ligand binding assay: suitable

杂质

<0.0005% Phosphorus (P)
<0.1% Insoluble matter

灼烧残渣

<0.1%

颜色

white

mp

195 °C (dec.) (lit.)

溶解性

H2O: 0.5 M at 20 °C, clear, colorless

痕量阴离子

chloride (Cl-): <0.04%
sulfate (SO42-): <0.05%

痕量阳离子

Al: <5 mg/kg
Ca: <20 mg/kg
Cu: <5 mg/kg
Fe: <5 mg/kg
K: <50 mg/kg
Mg: <50 mg/kg
NH4+: <500 mg/kg
Na: <70 mg/kg
Pb: <10 mg/kg
Zn: <5 mg/kg

SMILES字符串

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

基因信息

human ... SLC6A1(6529) , SLC6A11(6538) , SLC6A12(6539)
rat ... Gabra1(29705) , Gabra2(29706) , Olr1750(294204) , Slc6a1(79212) , Slc6a12(50676)

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相关类别

一般描述

γγ-氨基丁酸(GABA)是一种与大脑有关的非蛋白质氨基酸。在神经系统中合成，贮存于突触囊泡中。天然存在于绿茶、大豆、发芽稻米和一些发酵食品中。

应用

γγ-氨基丁酸(GABA)已用于处理背根神经节神经元进行电生理记录研究，以研究其对大鼠神经病理性疼痛的影响。它还用于检测其在小体积移植(SFSG)损伤模型的离体机械灌注系统中的保护作用。

生化/生理作用

γγ-氨基丁酸（GABA）是一种哺乳动物抑制性神经递质，具有多种功能。它对于中枢神经系统(CNS)的正常功能发挥至关重要。文献记录的GABA功能包括它在毒素诱导损伤中的保护作用。它还具有抗高血压、抗糖尿、抗微生物、抗氧化、抗过敏、抗炎和抗癌作用。GABA可能有益于人的压力和睡眠改善。γγ-氨基丁酸(GABA)可用于研究由GABA受体——GABAA和GABAB——介导的生物和生化过程。
大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Piril Hepsomali et al.
Frontiers in neuroscience, 14, 923-923 (2020-10-13)
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role
Dai-Hung Ngo et al.
Molecules (Basel, Switzerland), 24(15) (2019-07-28)
Gamma-aminobutyric acid (Gaba) is a non-proteinogenic amino acid that is widely present in microorganisms, plants, and vertebrates. So far, Gaba is well known as a main inhibitory neurotransmitter in the central nervous system. Its physiological roles are related to the
Li-Jie Wang et al.
Experimental and therapeutic medicine, 14(2), 1373-1380 (2017-08-16)
Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess
Vincent Paille et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(22), 9353-9363 (2013-05-31)
The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding learning and memory, relies on relative timing of neuronal activity on either side of the synapse. GABAergic signaling has been shown to control neuronal excitability and consequently the spike timing
Claudio Giachino et al.
Development (Cambridge, England), 141(1), 83-90 (2013-11-29)
Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express
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